Determination of montelukast by new spectrophotometric method using bromocresol green

The proposed method is simple, direct, sensitive and do not require any extraction process. [...]this method could be readily applicable for the quality control and routine analysis. Several methods have been reported in the literature for the analysis of Montelukast Sodium such as Liquid chromatogr...

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Published in:Research journal of pharmacy and technology 2021, Vol.14 (1), p.445-449
Main Authors: Sarkis, Nazira, Antakli, Saad, Alhamada, Zakaa
Format: Article
Language:English
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Summary:The proposed method is simple, direct, sensitive and do not require any extraction process. [...]this method could be readily applicable for the quality control and routine analysis. Several methods have been reported in the literature for the analysis of Montelukast Sodium such as Liquid chromatographic (LC)4-5, High performance liquid chromatographic (HPLC) and high-performance thin layer chromatographic (HPTLC)6-7, Voltammetric method8-9, Spectrophotometric method10-11, Reverse phase high performance liquid chromatographic (RPHPLC) method12-13, Ultra Performance Liquid Chromatography (UPLC) method14. Stock solutions 1.64x10-3 M of Montelukast Sodium (Mw = 608.169g/mol) was prepared by dissolving 10mg of pharmaceutically pure raw material sample equivalent to 10.04mg (by taken the purity in consideration) in volumetric flask 10mL of Dichloromethane, then 1mL of the solution was taken to volumetric flask 10mL and diluted with Dichloromethane to give concentration 1.64x10-4 M equivalent to 100^g/mL. The mean molar absorptivity 8, Sandell's sensitivity, limit of detection (LOD) and limit of quantification (LOQ) were calculated from the standard deviation of the absorbance measurements obtained from Beer's law and are presented in table 2.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.5958/0974-360X.2021.00081.0