Optimal control strategies to tailor antivirals for acute infectious diseases in the host

Several mathematical models in SARS-CoV-2 have shown how target-cell model can help to understand the spread of the virus in the host and how potential candidates of antiviral treatments can help to control the virus. Concepts as equilibrium and stability show to be crucial to qualitatively determin...

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Bibliographic Details
Published in:arXiv.org 2021-06
Main Authors: Perez, Mara, Abuin, Pablo, Actis, Marcelo, Ferramosca, Antonio, Hernandez-Vargas, Esteban A, Gonzalez, Alejandro H
Format: Article
Language:English
Subjects:
Control stability
Dosage
Infectious diseases
Mathematical models
Optimal control
Schedules
Severe acute respiratory syndrome coronavirus 2
Viral diseases
Viruses
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Summary:Several mathematical models in SARS-CoV-2 have shown how target-cell model can help to understand the spread of the virus in the host and how potential candidates of antiviral treatments can help to control the virus. Concepts as equilibrium and stability show to be crucial to qualitatively determine the best alternatives to schedule drugs, according to effectivity in inhibiting the virus infection and replication rates. Important biological events such as rebounds of the infections (when antivirals are incorrectly interrupted) can also be explained by means of a dynamic study of the target-cell model. In this work, a full characterization of the dynamical behavior of the target-cell models under control actions is made and, based on this characterization, the optimal fixed-dose antiviral schedule that produces the smallest amount of dead cells (without viral load rebounds) is computed. Several simulation results - performed by considering real patient data - show the potential benefits of both, the model characterization and the control strategy.
ISSN:2331-8422