Effects of Prenatal and Early Postnatal Administration of Valproate on Behavior and Cyhtological Characteristics in Wistar Rats

Prenatal administration of valproic acid (VA) and its salts is a common approach to modeling impairments to nervous system development; the sequelae of postnatal VA administration have received significantly less study. This study compared the behavioral characteristics of two groups of infant mice...

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Bibliographic Details
Published in:Neuroscience and behavioral physiology 2021-06, Vol.51 (5), p.639-647
Main Authors: Gedzun, V. R., Svinov, M. M., Sarycheva, N. Yu, Shlapakova, P. S., Dovbnyuk, K. O., Dubynin, V. A.
Format: Article
Language:English
Subjects:
Behavior
Behavioral Sciences
Biomedical and Life Sciences
Biomedicine
Complications
Cortex (cingulate)
Emotional behavior
Hyperactivity
Limbic system
Nervous system
Neurobiology
Neurosciences
Oligodendrocytes
Salts
Social interactions
Sodium valproate
Valproic acid
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Summary:Prenatal administration of valproic acid (VA) and its salts is a common approach to modeling impairments to nervous system development; the sequelae of postnatal VA administration have received significantly less study. This study compared the behavioral characteristics of two groups of infant mice exposed to sodium valproate pre- and postnatally; neurocytological methods were also used. Behavioral studies were started from the early postnatal period and ended at age 36 days. Comparison of models showed a delay in early motor development and hyperactivity in both cases, though decreases in interest in new social contacts (interaction with rat pups of the same age) were seen only in animals given postnatal VA injections. In addition, a significant increase in the number of perineuronal satellite oligodendrocytes was seen in the anterior cingulate cortex of animals in both series – pre- and postnatal VA. Studies of the cingulate cortex, a component of the limbic system, are important in considering social interactions and the processes forming and regulating emotional behavior, as well as pathological reactions in different impairments to higher brain functions.
ISSN:0097-0549
1573-899X
DOI:10.1007/s11055-021-01117-y