Electrophoretic Deposition of Gentamicin-Loaded ZnHNTs-Chitosan on Titanium

There is a need for titanium (Ti), an antimicrobial implant coating that provides sustained protection against bacterial infection. Chitosan (CS) coatings, combined with halloysite nanotubes (HNTs), are an attractive solution due to the inherent biocompatibility of halloysite, its ability to provide...

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Bibliographic Details
Published in:Coatings (Basel) 2020-10, Vol.10 (10), p.944
Main Authors: Humayun, Ahmed, Luo, Yangyang, Mills, David K.
Format: Article
Language:English
Subjects:
Alcohol
Analysis
Anti-infective agents
Antibiotics
Antiinfectives and antibacterials
Antimicrobial agents
Biocompatibility
Biofilms
Biomedical materials
Body fluids
Cell growth
Chitin
Chitosan
Coated electrodes
Composition
Electrophoretic deposition
Fourier transforms
Gentamicin
Growth factors
Halloysite
Hydroxyapatite
Implants, Artificial
Infrared spectroscopy
Materials
Metal foils
Methods
Nanoparticles
Nanotubes
Power supply
Prosthesis
Silicon carbide
Surgical implants
Titanium
Transplants & implants
X ray powder diffraction
X-ray fluorescence
Zinc
Zinc coatings
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Summary:There is a need for titanium (Ti), an antimicrobial implant coating that provides sustained protection against bacterial infection. Chitosan (CS) coatings, combined with halloysite nanotubes (HNTs), are an attractive solution due to the inherent biocompatibility of halloysite, its ability to provide sustained drug release, and the antimicrobial properties of CS. In this study, the electrodeposition (EPD) method was used to coat titanium foil with CS blended with zinc-coated HNTs (ZnHNTs) and pre-loaded with the antibiotic gentamicin. The CS-ZnHNTs-gentamycin sulfate (GS) coatings were characterized using scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), X-ray powder diffraction (XRD), X-ray fluorescence (XRF), Fourier-transform infrared spectroscopy (FTIR), and UV-visible spectroscopy. The coatings were further examined for their ability to sustain GS release, resist bacterial colonization and growth, and prevent biofilm formation. The CS-ZnHNTs-GS coatings were cytocompatible, exhibited significant antimicrobial properties, and supported pre-osteoblast cell proliferation. Hydroxyapatite also formed on the coatings after immersion in simulated body fluid. While the focus in this study was on zinc-coated HNTs doped into CS, our design offers tunability, as different metals can be coated onto the HNT surface and different drugs or growth factors loaded into the HNT lumen. Our results, and the potential for customization, suggest that these coatings have potential in the construction of an array of infection-resistant implant coatings.
ISSN:2079-6412
2079-6412
DOI:10.3390/coatings10100944