System Xc−: a key regulatory target of ferroptosis in cancer

Summary Ferroptosis is a type of oxidative stress-dependent regulated necrosis characterized by excessive lipid peroxide accumulation. This novel cell death modality has been implicated in preventing cancer progression. Cancer cells tend to modulate their redox state to prevent excessive peroxidatio...

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Bibliographic Details
Published in:Investigational new drugs 2021-08, Vol.39 (4), p.1123-1131
Main Authors: Liu, Man-ru, Zhu, Wen-tao, Pei, Dong-sheng
Format: Article
Language:English
Subjects:
Amino Acid Transport System y+ - metabolism
Animals
Antineoplastic Agents - pharmacology
Biomarkers
Cancer
Cell death
Cell proliferation
Cell Proliferation - physiology
Chemotherapy
Cystine
Drug tolerance
Ferroptosis
Ferroptosis - drug effects
Humans
Lipids
Medical prognosis
Medicine
Medicine & Public Health
Metastases
Necrosis
Neoplasms - drug therapy
Neoplasms - pathology
Oncology
Oxidation-Reduction
Oxidative stress
Oxidative Stress - physiology
Peroxidation
Peroxide
Pharmacology/Toxicology
Redox properties
Review
Sensitivity enhancement
Tumor microenvironment
Tumors
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