Extraction of Acetals of Phenyl-Propargyl Aldehyde Using the Metod of Liquid Column Chromotography

The interreaction of substrates containing cyclopropane fragment with initial allyl and butyl alcohol, the influence of bromide atom in a gem-dichlorocyclopropane ring on the direction of the reaction with alcohol. The reaction of O-alkyllation 2-bromide-2-phenyl-gem-dichlorocyclopropane with alcoho...

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Bibliographic Details
Published in:IOP conference series. Earth and environmental science 2020-04, Vol.459 (4), p.42005
Main Authors: Aminova, E K, Fomina, V V, Krasnov, A N
Format: Article
Language:English
Subjects:
Acetals
Alcohol
Aldehydes
Butanol
Catalysts
Cyclopropane
Dimethylformamide
Phase transfer catalysts
Sodium hydroxide
Substrates
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Summary:The interreaction of substrates containing cyclopropane fragment with initial allyl and butyl alcohol, the influence of bromide atom in a gem-dichlorocyclopropane ring on the direction of the reaction with alcohol. The reaction of O-alkyllation 2-bromide-2-phenyl-gem-dichlorocyclopropane with alcohol in dimethylformamide with solid sodium hydroxide and without a phase transfer catalyst occurs selectively and produces the corresponding acetals of phenyl-propargyl aldehyde. The optimal conditions were selected for the reaction. It was researched and established that gem-dichlorocyclopropanes with a bromide atom in the cycle can also participate in such transformations. Acetals of phenyl-propargyl aldehyde were extracted from the reaction mix using the method of liquid column chromotography
ISSN:1755-1307
1755-1315
DOI:10.1088/1755-1315/459/4/042005