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Regioselective Synthesis of 5H-Benzo[4,5]imidazo[2,1-a]isoindole Linked 1,2,3-Traizole Hybrids and Their Anti-Proliferative Activity
Copper(I) catalyzed regioselective synthesis of some novel 5 H -benzo[4,5]imidazo[2,1- a ]isoindole linked 1,2,3-traizole hybrids has been developed. Structures of the synthesized compounds have been confirmed by IR, 1 H, and 13 C NMR, and mass spectra. The in vitro tests against four human cancer c...
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| Published in: | Russian journal of general chemistry 2021-06, Vol.91 (6), p.1135-1139 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c285t-a8ad4eb91cbc9f0f4bdf3909aca0d29712483d621a1e8f63ceccc7f304f1c46c3 |
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| cites | cdi_FETCH-LOGICAL-c285t-a8ad4eb91cbc9f0f4bdf3909aca0d29712483d621a1e8f63ceccc7f304f1c46c3 |
| container_end_page | 1139 |
| container_issue | 6 |
| container_start_page | 1135 |
| container_title | Russian journal of general chemistry |
| container_volume | 91 |
| creator | Reddy, M. Srinivas Swamy, T. Narasimha Ravinder, M. Nukala, Satheesh Kumar |
| description | Copper(I) catalyzed regioselective synthesis of some novel 5
H
-benzo[4,5]imidazo[2,1-
a
]isoindole linked 1,2,3-traizole hybrids has been developed. Structures of the synthesized compounds have been confirmed by IR,
1
H, and
13
C NMR, and mass spectra. The
in vitro
tests against four human cancer cell lines, MCF-7, HeLa, A549, and IMR32, have exhibited notable anticancer activity of some products comparable with that of the standard drug etoposide. Molecular docking studies carried out with epidermal growth factor receptor (PDB ID- 4HJO) have supported anticancer activity of the compounds. |
| doi_str_mv | 10.1134/S1070363221060232 |
| format | article |
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a
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1
H, and
13
C NMR, and mass spectra. The
in vitro
tests against four human cancer cell lines, MCF-7, HeLa, A549, and IMR32, have exhibited notable anticancer activity of some products comparable with that of the standard drug etoposide. Molecular docking studies carried out with epidermal growth factor receptor (PDB ID- 4HJO) have supported anticancer activity of the compounds.</description><identifier>ISSN: 1070-3632</identifier><identifier>EISSN: 1608-3350</identifier><identifier>DOI: 10.1134/S1070363221060232</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Anticancer properties ; Cancer ; Chemical synthesis ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Growth factors ; Hydrogen ; Hydrogen bonding ; In vitro methods and tests ; Mass spectra ; Molecular docking ; NMR ; Nuclear magnetic resonance ; Regioselectivity ; Triazoles</subject><ispartof>Russian journal of general chemistry, 2021-06, Vol.91 (6), p.1135-1139</ispartof><rights>Pleiades Publishing, Ltd. 2021</rights><rights>COPYRIGHT 2021 Springer</rights><rights>Pleiades Publishing, Ltd. 2021.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c285t-a8ad4eb91cbc9f0f4bdf3909aca0d29712483d621a1e8f63ceccc7f304f1c46c3</citedby><cites>FETCH-LOGICAL-c285t-a8ad4eb91cbc9f0f4bdf3909aca0d29712483d621a1e8f63ceccc7f304f1c46c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Reddy, M. Srinivas</creatorcontrib><creatorcontrib>Swamy, T. Narasimha</creatorcontrib><creatorcontrib>Ravinder, M.</creatorcontrib><creatorcontrib>Nukala, Satheesh Kumar</creatorcontrib><title>Regioselective Synthesis of 5H-Benzo[4,5]imidazo[2,1-a]isoindole Linked 1,2,3-Traizole Hybrids and Their Anti-Proliferative Activity</title><title>Russian journal of general chemistry</title><addtitle>Russ J Gen Chem</addtitle><description>Copper(I) catalyzed regioselective synthesis of some novel 5
H
-benzo[4,5]imidazo[2,1-
a
]isoindole linked 1,2,3-traizole hybrids has been developed. Structures of the synthesized compounds have been confirmed by IR,
1
H, and
13
C NMR, and mass spectra. The
in vitro
tests against four human cancer cell lines, MCF-7, HeLa, A549, and IMR32, have exhibited notable anticancer activity of some products comparable with that of the standard drug etoposide. Molecular docking studies carried out with epidermal growth factor receptor (PDB ID- 4HJO) have supported anticancer activity of the compounds.</description><subject>Anticancer properties</subject><subject>Cancer</subject><subject>Chemical synthesis</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Growth factors</subject><subject>Hydrogen</subject><subject>Hydrogen bonding</subject><subject>In vitro methods and tests</subject><subject>Mass spectra</subject><subject>Molecular docking</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Regioselectivity</subject><subject>Triazoles</subject><issn>1070-3632</issn><issn>1608-3350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp1kUFPGzEQhVdVkUqBH8BtpV5jGNu73t1jQKVBigQq4YTQyrHHYejGpvZSKZz7w3EIUg8Vp3maed-8kaYojjmccC6r0xsODUglheCgQEjxqdjnClomZQ2fs85jtp1_Kb6m9AjAAZTYL_7-xBWFhAOakf5gebPx4wMmSmVwZT1jZ-hfwl01qe9pTVZnLSac6XtKgbwNA5Zz8r_QlnwiJpItoqaXbXe2WUayqdTelosHpFhO_UjsOoaBHEb9FjbdZtK4OSz2nB4SHr3Xg-L24vvifMbmVz8uz6dzZkRbj0y32la47LhZms6Bq5bWyQ46bTRY0TVcVK20SnDNsXVKGjTGNE5C5biplJEHxbfd3qcYfj9jGvvH8Bx9juxFXatWNZWE7DrZuVZ6wJ68C2PMEUZbXJMJHh3l_rThrWw79QbwHWBiSCmi658irXXc9Bz67Xf6_76TGbFjUvb6FcZ_p3wMvQIqSJEd</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Reddy, M. Srinivas</creator><creator>Swamy, T. Narasimha</creator><creator>Ravinder, M.</creator><creator>Nukala, Satheesh Kumar</creator><general>Pleiades Publishing</general><general>Springer</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20210601</creationdate><title>Regioselective Synthesis of 5H-Benzo[4,5]imidazo[2,1-a]isoindole Linked 1,2,3-Traizole Hybrids and Their Anti-Proliferative Activity</title><author>Reddy, M. Srinivas ; Swamy, T. Narasimha ; Ravinder, M. ; Nukala, Satheesh Kumar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c285t-a8ad4eb91cbc9f0f4bdf3909aca0d29712483d621a1e8f63ceccc7f304f1c46c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Anticancer properties</topic><topic>Cancer</topic><topic>Chemical synthesis</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Growth factors</topic><topic>Hydrogen</topic><topic>Hydrogen bonding</topic><topic>In vitro methods and tests</topic><topic>Mass spectra</topic><topic>Molecular docking</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Regioselectivity</topic><topic>Triazoles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reddy, M. Srinivas</creatorcontrib><creatorcontrib>Swamy, T. Narasimha</creatorcontrib><creatorcontrib>Ravinder, M.</creatorcontrib><creatorcontrib>Nukala, Satheesh Kumar</creatorcontrib><collection>CrossRef</collection><jtitle>Russian journal of general chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reddy, M. Srinivas</au><au>Swamy, T. Narasimha</au><au>Ravinder, M.</au><au>Nukala, Satheesh Kumar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regioselective Synthesis of 5H-Benzo[4,5]imidazo[2,1-a]isoindole Linked 1,2,3-Traizole Hybrids and Their Anti-Proliferative Activity</atitle><jtitle>Russian journal of general chemistry</jtitle><stitle>Russ J Gen Chem</stitle><date>2021-06-01</date><risdate>2021</risdate><volume>91</volume><issue>6</issue><spage>1135</spage><epage>1139</epage><pages>1135-1139</pages><issn>1070-3632</issn><eissn>1608-3350</eissn><abstract>Copper(I) catalyzed regioselective synthesis of some novel 5
H
-benzo[4,5]imidazo[2,1-
a
]isoindole linked 1,2,3-traizole hybrids has been developed. Structures of the synthesized compounds have been confirmed by IR,
1
H, and
13
C NMR, and mass spectra. The
in vitro
tests against four human cancer cell lines, MCF-7, HeLa, A549, and IMR32, have exhibited notable anticancer activity of some products comparable with that of the standard drug etoposide. Molecular docking studies carried out with epidermal growth factor receptor (PDB ID- 4HJO) have supported anticancer activity of the compounds.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S1070363221060232</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1070-3632 |
| ispartof | Russian journal of general chemistry, 2021-06, Vol.91 (6), p.1135-1139 |
| issn | 1070-3632 1608-3350 |
| language | eng |
| recordid | cdi_proquest_journals_2556867430 |
| source | Springer Nature:Jisc Collections:Springer Nature Read and Publish 2023-2025: Springer Reading List |
| subjects | Anticancer properties Cancer Chemical synthesis Chemistry Chemistry and Materials Science Chemistry/Food Science Growth factors Hydrogen Hydrogen bonding In vitro methods and tests Mass spectra Molecular docking NMR Nuclear magnetic resonance Regioselectivity Triazoles |
| title | Regioselective Synthesis of 5H-Benzo[4,5]imidazo[2,1-a]isoindole Linked 1,2,3-Traizole Hybrids and Their Anti-Proliferative Activity |
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