Biomarkers of Aging and Micronutrient Status in Frailty

Background/Aims: Frailty, a geriatric syndrome, is considered as a major public health concern among older adults. It is a multidimensional biological process resulting from interaction of different pathways, including multiple anabolic deficiency, oxidative stress, inflammation, and poor nutritiona...

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Bibliographic Details
Published in:Annals of nutrition and metabolism 2019-01, Vol.75, p.91
Main Authors: Reddy, G Bhanuprakash, Shalini, T, Sivaprasad, M, Kumar, B Naveen
Format: Article
Language:English
Subjects:
Adults
Advanced glycosylation end products
Aging
Albumins
Aldehyde reductase
Biological activity
Biological effects
Biomarkers
Carbonyl compounds
Carbonyls
Community involvement
Creatinine
Erythrocytes
Fluorescence spectroscopy
Frailty
Geriatrics
Glycosylation
Growth factors
Hemoglobin
High-performance liquid chromatography
Homocysteine
Insulin
Insulin-like growth factor I
Interleukin 6
Interleukins
Liquid chromatography
Nutrient deficiency
Nutrition
Nutritional status
Older people
Oxidative stress
Plasma levels
Public health
Reductases
Sorbitol
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Summary:Background/Aims: Frailty, a geriatric syndrome, is considered as a major public health concern among older adults. It is a multidimensional biological process resulting from interaction of different pathways, including multiple anabolic deficiency, oxidative stress, inflammation, and poor nutritional status. The study aimed to investigate the micronutrient status and biomarkers of aging and their association with frailty. Methods: This communitybased cross-sectional study involved 125 older adults aged ≥60 years residing in Hyderabad, India. Anthropometric data, clinical parameters, and micronutrient status were assessed. Plasma levels of advanced glycation end products (AGEs) were assessed cumulatively as AGE-index (AGI) by spectrofluorometry. Erythrocyte aldose reductase (ALR2) activity and plasma protein carbonyls were analyzed by spectrophotometer, while erythrocyte sorbitol level was determined by by spectrofluorometer. Meanwhile, plasma homocysteine was assessed by HPLC and interleukin (IL-6) as well as insulin-like growth factor (IGF-1) were determined using ELISA. Results: The prevalence of frailty was 25% among the subjects and it was higher in anemic group (37%) than in the normal group (20%). The prevalence of micronutrient deficiency was high in the frail group. Moreover, in the frail group, urinary albumin to creatinine ratio was significantly high and hemoglobin was significantly low. Furthermore, median values of ALR2, AGI, and IL6, were significantly high, while IGF-1 was significantly low in the frail group. Interestingly, 64% of frail individuals had hyperhomocysteinemia (>15 μmol/L). Conclusions: Micronutrient status had influence on biomarkers of aging that are associated with frailty. A better understanding of these markers along with micronutrient status could aid in developing suitable intervention strategies to this multidimensional process in older adults.
ISSN:0250-6807
1421-9697
DOI:10.1159/000501751