Effect of Bifidobacterium on olanzapine-induced body weight and appetite changes in patients with psychosis

Rationale Gut microbiota plays an important role in host metabolism. Antipsychotic drugs can result in metabolic abnormalities. Probiotics may ameliorate the antipsychotic drug-induced metabolic abnormalities by regulating gut microbiota. Objective To determine whether Bifidobacterium intervention c...

Full description

Saved in:
Bibliographic Details
Published in:Psychopharmacology 2021-09, Vol.238 (9), p.2449-2457
Main Authors: Yang, Ye, Long, Yujun, Kang, Dongyu, Liu, Chenchen, Xiao, Jingmei, Wu, Renrong, Zhao, Jingping
Format: Article
Language:English
Subjects:
Antipsychotics
Appetite
Bifidobacterium
Biomedical and Life Sciences
Biomedicine
Body mass index
Body weight
Body weight gain
Drug metabolism
Evaluation
Intestinal microflora
Latency
Mental disorders
Metabolism
Microbiota
Neurosciences
Olanzapine
Original Investigation
Patients
Pharmacology/Toxicology
Physiological aspects
Probiotics
Psychiatry
Psychological aspects
Psychosis
Psychotropic drugs
Schizophrenia
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Rationale Gut microbiota plays an important role in host metabolism. Antipsychotic drugs can result in metabolic abnormalities. Probiotics may ameliorate the antipsychotic drug-induced metabolic abnormalities by regulating gut microbiota. Objective To determine whether Bifidobacterium intervention can ameliorate olanzapine-induced weight increase. Methods Enrolled patients were assigned to either the olanzapine or olanzapine plus Bifidobacterium group. The following were assessed: body weight, body mass index (BMI), appetite, latency to increased appetite, and baseline weight increase of more than 7%. All assessments were conducted at baseline and at 4, 8, and 12 weeks of treatment. Results We enrolled 70 patients with schizophrenia or schizophrenic affective disorder, and 67 completed the study. Treatment for 4 weeks led to between-group differences in weight change (2.4 vs. 1.1 kg, p   0.05). The mean time from olanzapine initiation to appetite increase was also not significantly different between the two groups ( t  = 1.243, p  = 0.220). Conclusions Probiotics may mitigate olanzapine-induced weight gain in the early stage of treatment and delay olanzapine-induced appetite increase.
ISSN:0033-3158
1432-2072
DOI:10.1007/s00213-021-05866-z