Burden of Respiratory Syncytial Virus Infection During the First Year of Life

Abstract Background Although many infants with respiratory syncytial virus (RSV) infection are hospitalized, most infants are treated as outpatients. Limited data are available on the burden of RSV in outpatient infants. Methods In a prospective study, we enrolled 431 newborn infants and followed th...

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Bibliographic Details
Published in:The Journal of infectious diseases 2021-03, Vol.223 (5), p.811-817
Main Authors: Thomas, Emilia, Mattila, Janna-Maija, Lehtinen, Pasi, Vuorinen, Tytti, Waris, Matti, Heikkinen, Terho
Format: Article
Language:English
Subjects:
Antibiotics
Antiviral drugs
Ear diseases
Hospitalization
Humans
Infant
Infant, Newborn
Infants
Infections
Monoclonal antibodies
Otitis media
Otitis Media - epidemiology
Prospective Studies
Respiratory syncytial virus
Respiratory Syncytial Virus Infections - epidemiology
Respiratory Syncytial Virus, Human
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Summary:Abstract Background Although many infants with respiratory syncytial virus (RSV) infection are hospitalized, most infants are treated as outpatients. Limited data are available on the burden of RSV in outpatient infants. Methods In a prospective study, we enrolled 431 newborn infants and followed them up for a 10-month period (September–June). During each respiratory illness, we examined the infants and obtained nasopharyngeal specimens for the detection of RSV. The parents completed daily symptom diaries throughout the study. Results Among 408 active participants, the seasonal incidence rate of RSV illness was 328.4 per 1000 (95% confidence interval [CI], 275.2–389.0). Infants with ≥1 sibling had a 1.9-fold higher incidence of RSV illness than those without siblings (95% CI, 1.3–2.8; P 
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jiaa754