Fabrication and fluorescence imaging properties of indocyanine green-loaded poly(lactic-co-glycolic acid) nanoparticles

This work proposed a method for fabricating poly(lactic-co-glycolic acid) (PLGA) nanoparticles (ca. 70 nm) loaded with indocyanine green (ICG) molecules by an antisolvent crystallization method using dimethyl sulfoxide (DMSO) as a good solvent and water as a poor solvent. ICG molecules were loaded t...

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Bibliographic Details
Published in:Colloid and polymer science 2021-08, Vol.299 (8), p.1271-1283
Main Authors: Tayama, Mayu, Inose, Tomoya, Yamauchi, Noriko, Nakashima, Kouichi, Tokunaga, Masayuki, Kato, Chihiro, Gonda, Kohsuke, Kobayashi, Yoshio
Format: Article
Language:English
Subjects:
Albumins
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Complex Fluids and Microfluidics
Crystallization
Dimethyl sulfoxide
Fluorescence
Food Science
Glycolic acid
Nanoparticles
Nanotechnology and Microengineering
Original Contribution
Physical Chemistry
Polyethylene glycol
Polyethyleneimine
Polymer Sciences
Polyvinyl alcohol
Soft and Granular Matter
Solvents
Spleen
Tumors
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Summary:This work proposed a method for fabricating poly(lactic-co-glycolic acid) (PLGA) nanoparticles (ca. 70 nm) loaded with indocyanine green (ICG) molecules by an antisolvent crystallization method using dimethyl sulfoxide (DMSO) as a good solvent and water as a poor solvent. ICG molecules were loaded to PLGA nanoparticles by mixing PLGA, polyethylenimine, and polyethylene glycol (PEG) in DMSO with polyvinyl alcohol, albumin, and ICG in water. The ICG-loaded PLGA nanoparticle colloid solutions emitted fluorescence even at high ICG concentrations. Not only the tissues of a tumor-bearing mouse but also the tumor could be imaged with an IVIS system by injecting ICG-loaded PLGA nanoparticle colloid solution into the tail vein of the mouse and measuring the emitted fluorescence intensity, though some ICG-loaded PLGA nanoparticles were trapped in tissues such as the liver and spleen due to insufficient PEGylation. Thus, this work showed that ICG-loaded PLGA nanoparticles have potential for cancer imaging. Graphical abstract
ISSN:0303-402X
1435-1536
DOI:10.1007/s00396-021-04844-3