Size dependent mechanistic activity of titanium dioxide nanoparticles for enhanced fibroblast cell proliferation and anti-bacterial activity

Many biomedical applications, titanium dioxide (TiO 2 ) nanoparticles are used. They have been used for drugs delivery and targeting, skin tone protection, reinforcement materials etc. It is biocompatible and non-toxic in nature. The healing of wounds are delayed mainly due to infections. Infections...

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Bibliographic Details
Published in:Journal of sol-gel science and technology 2021-09, Vol.99 (3), p.565-575
Main Authors: Venkataprasanna, K. S., Prakash, J., Anusuya, T., Devanand Venkatasubbu, G.
Format: Article
Language:English
Subjects:
Antimicrobial agents
Biocompatibility
Biomedical materials
Cell growth
Ceramics
Chemical synthesis
Chemistry and Materials Science
Composites
Fibroblasts
Fourier transforms
Glass
Inorganic Chemistry
Materials Science
Nanomaterials
Nanoparticles
Nanotechnology
Natural Materials
Optical and Electronic Materials
Original Paper: Sol-gel and hybrid materials for biological and health (medical) applications
Particle size
Phase transitions
Surgical implants
Titanium
Titanium dioxide
Wound healing
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Summary:Many biomedical applications, titanium dioxide (TiO 2 ) nanoparticles are used. They have been used for drugs delivery and targeting, skin tone protection, reinforcement materials etc. It is biocompatible and non-toxic in nature. The healing of wounds are delayed mainly due to infections. Infections make the process of wound healing complex. Nanomaterials are used for enhancing wound healing mainly due to their ability to inhibit bacterial growth. Nanoparticles of TiO 2 are synthesized using a chemical method. They are annealed at different temperature to increase the particle size. XRD (X-ray diffraction), FTIR (Fourier Transform infrared spectroscopy), and TEM (Transmission electron Microscopy) are used to classify the samples. The influence of particle size and phase transformation on fibroblast cell proliferation. F-actin, cell movement are analysed. It is found that the antimicrobial activity increases with decrease in particle size. This study confirms the utilization of TiO 2 nanoparticles for wound healing applications. Highlights Influence of particle size on Fibroblast growth is analyzed. Influence of particle size on antimicrobial activity is analyzed. The role of F-actin is imaged. Cell migration studies confirms enhanced wound healing. Staining studies confirms the cell proliferation.
ISSN:0928-0707
1573-4846
DOI:10.1007/s10971-021-05600-3