Advanced Kinetic Modeling of Bio-co-polymer Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Production Using Fructose and Propionate as Carbon Sources

Biopolymers are a promising alternative to petroleum-based plastic raw materials. They are bio-based, non-toxic and degradable under environmental conditions. In addition to the homopolymer poly(3-hydroxybutyrate) (PHB), there are a number of co-polymers that have a broad range of applications and a...

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Bibliographic Details
Published in:Processes 2021-08, Vol.9 (8), p.1260
Main Authors: Duvigneau, Stefanie, Dürr, Robert, Behrens, Jessica, Kienle, Achim
Format: Article
Language:English
Subjects:
Bacteria
Biomass
Biopolymers
Carbon
Carbon dioxide
Carbon sources
Chromatography
Copolymers
Environmental conditions
Exhaust gases
Experiments
Feed rate
Fructose
Mathematical models
Metabolism
Microorganisms
Polyhydroxybutyrate
Polymers
Process controls
Process parameters
Propionic acid
Raw materials
Research methodology
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Summary:Biopolymers are a promising alternative to petroleum-based plastic raw materials. They are bio-based, non-toxic and degradable under environmental conditions. In addition to the homopolymer poly(3-hydroxybutyrate) (PHB), there are a number of co-polymers that have a broad range of applications and are easier to process in comparison to PHB. The most prominent representative from this group of bio-copolymers is poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV). In this article, we show a new kinetic model that describes the PHBV production from fructose and propionic acid in Cupriavidus necator (C. necator). The developed model is used to analyze the effects of process parameter variations such as the CO2 amount in the exhaust gas and the feed rate. The presented model is a valuable tool to improve the microbial PHBV production process. Due to the coupling of CO2 online measurements in the exhaust gas to the biomass production, the model has the potential to predict the composition and the current yield of PHBV in the ongoing process.
ISSN:2227-9717
2227-9717
DOI:10.3390/pr9081260