Acetaminophen elevates unbound bilirubin levels by the glucose oxidase‐peroxidase method

Background Acetaminophen is widely administered to neonates but its effect on unbound bilirubin (UB) levels remains unclear. The aim of this study was to clarify whether administration of acetaminophen is related to an elevation of UB levels. Method Infants with a birthweight of ˂1,500 g admitted to...

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Bibliographic Details
Published in:Pediatrics international 2021-09, Vol.63 (9), p.1069-1074
Main Authors: Ichimura, Shintaro, Kakita, Hiroki, Asai, Shimpei, Mori, Mari, Takeshita, Satoru, Ueda, Hiroko, Kondo, Tomoko, Ohashi, Wataru, Okumura, Akihisa, Yamada, Yasumasa
Format: Article
Language:English
Subjects:
Acetaminophen
Acetaminophen - adverse effects
Analgesics
Bilirubin
Birth weight
Gastrointestinal diseases
Glucose Oxidase
Humans
Infant
Infant, Newborn
Infants
Jaundice, Neonatal
Multivariate analysis
neonatal jaundice
Neonates
Neurotoxicity
Oxidoreductases
paracetamol
Pediatrics
Peroxidase
Peroxidases
Retrospective Studies
unbound bilirubin
very‐low‐birthweight infants
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Summary:Background Acetaminophen is widely administered to neonates but its effect on unbound bilirubin (UB) levels remains unclear. The aim of this study was to clarify whether administration of acetaminophen is related to an elevation of UB levels. Method Infants with a birthweight of ˂1,500 g admitted to our neonatal intensive care unit between January 2017 and April 2020 were retrospectively reviewed. Seventy‐one infants were enrolled, five of whom had received acetaminophen. Clinical data were analyzed when the highest UB value (UB peak) in each infant was recorded. Demographic data and information on treatment within the 24 h before the UB peak were also collected. UB was determined by the glucose oxidase‐peroxidase (GOD‐POD) method. Infants were categorized according to the presence or absence of acetaminophen administration (acetaminophen and no acetaminophen groups) within 24 h of the UB peak. The relationship between UB values and various clinical variables was then compared. Results Both the peak UB value and the ratio of gastrointestinal disease were higher in the acetaminophen group than in the no acetaminophen group. Univariate analysis revealed that a total of seven variables were potentially correlated with UB peak values (P 
ISSN:1328-8067
1442-200X
DOI:10.1111/ped.14608