Smart controlled release of acarbose from glucose‐sensitive hydrogels comprising covalently modified carboxylated pullulan and concanavalin A

A hydrogel comprising covalently modified carboxylated pullulan and concanavalin A (CPUL‐ConA) was prepared with glucose‐sensitivity in a simulated small intestinal fluid containing glucose. The acarbose‐encapsulated CPUL‐ConA (Acar/CPUL‐ConA) hydrogel, with an acarbose encapsulation ratio of 0.63,...

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Bibliographic Details
Published in:Journal of applied polymer science 2021-12, Vol.138 (48), p.n/a
Main Authors: Yi, Ju‐Zhen, Lin, Kunhua, Wu, Hao, Mao, Xuhong, Zhang, Li‐Ming, Yang, Liqun
Format: Article
Language:English
Subjects:
Concanavalin A
Controlled release
drug delivery systems
Encapsulation
gels
Glucose
Glucosidase
Hydrogels
Hyperglycemia
Intestine
Materials science
Polymers
polysaccharides
Pullulan
Rheological properties
rheology
Shear thinning (liquids)
Simulation
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Summary:A hydrogel comprising covalently modified carboxylated pullulan and concanavalin A (CPUL‐ConA) was prepared with glucose‐sensitivity in a simulated small intestinal fluid containing glucose. The acarbose‐encapsulated CPUL‐ConA (Acar/CPUL‐ConA) hydrogel, with an acarbose encapsulation ratio of 0.63, was prepared by immersing the dried CPUL‐ConA hydrogel in an acarbose/PBS (pH 7.2) solution. In the simulated gastric fluid, less than 20% acarbose was released from the Acar/CPUL‐ConA hydrogel, which could be beneficial to protecting the stomach. In contrast, more than 80% acarbose was smartly controlled released from the Acar/CPUL‐ConA hydrogel in the simulated small intestine fluid containing glucose. Scanning electron microscopy provided further evidence of the smart release of acarbose from the Acar/CPUL‐ConA hydrogel in simulated gastrointestinal fluids, which is advantageous to inhibiting α‐glucosidase activity and subsequently reducing the postprandial blood glucose levels, as well as helpful for reducing the gastrointestinal dysfunction of acarbose. Rheological analysis indicated that the Acar/CPUL‐ConA hydrogel showed characteristics of chemical crosslinked hydrogels. There was no obvious shear thinning behavior, suggesting that the Acar/CPUL‐ConA hydrogel could be stable under gastric and intestinal peristalsis. Therefore, the Acar/CPUL‐ConA hydrogel is anticipated to improve the therapeutic efficacy of postprandial hyperglycemia and type 2 diabetes.
ISSN:0021-8995
1097-4628
DOI:10.1002/app.51553