CoNi alloy nanoparticles for cancer theranostics: synthesis, physical characterization, in vitro and in vivo studies

Nanomaterials are attracting increasing interest in many biomedical fields, including the fight against cancer. In this context, we successfully synthesized CoNi alloy nanoparticles (NPs) by a simple polyol process. The magnetic characteristics of the products were measured by vibration sample magno...

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Bibliographic Details
Published in:Applied physics. A, Materials science & processing Materials science & processing, 2021-10, Vol.127 (10), Article 772
Main Authors: Sargazi, Saman, Hajinezhad, Mohammad Reza, Rahdar, Abbas, Mukhtar, Mahwash, Karamzadeh-Jahromi, Milad, Almasi-Kashi, Mohammad, Alikhanzadeh-Arani, Sima, Barani, Mahmood, Baino, Francesco
Format: Article
Language:English
Subjects:
Alanine
Applied physics
Biocompatibility
Biomedical materials
Cancer
Catalase
Cell death
Characterization and Evaluation of Materials
Condensed Matter Physics
Creatinine
Endothelial cells
Ferromagnetism
In vivo methods and tests
Intermetallic compounds
Lactate dehydrogenase
Leakage
Liver
Machines
Magnetic properties
Malondialdehyde
Manufacturing
Materials science
Morphology
Nanoalloys
Nanomaterials
Nanoparticles
Nanotechnology
Optical and Electronic Materials
Physics
Physics and Astronomy
Precision medicine
Processes
Superoxide dismutase
Surfaces and Interfaces
Thin Films
Toxicity
Vibration measurement
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Summary:Nanomaterials are attracting increasing interest in many biomedical fields, including the fight against cancer. In this context, we successfully synthesized CoNi alloy nanoparticles (NPs) by a simple polyol process. The magnetic characteristics of the products were measured by vibration sample magnometry, which revealed that the samples have soft ferromagnetic behavior. The microstructure and morphology were inspected by X-ray diffraction and scanning electron microscopy, respectively. Human cancer cells derived from the breast (MCF7) and oral cavity (C152) and normal cells derived from human umbilical vein endothelial cells (HUVECs) were treated with increasing concentrations of CoNi NPs, and their cytotoxic effect was measured via MTT and lactate dehydrogenase (LDH) leakage assays. We found that treatments by using 12.5 to 400 µg/mL of Co0.5Ni0.5, Co0.6Ni0.4, and Co0.4Ni0.6 NPs were associated with significant concentration-dependent toxicity toward such cell lines and profoundly enhanced LDH leakage following 48 h of exposure ( P  
ISSN:0947-8396
1432-0630
DOI:10.1007/s00339-021-04917-8