Therapeutic effect of rutin-loaded poly lactic-co-glycolic acid nanoparticles on gingiva of periodontitis rats

Periodontitis is a chronic infectious disease of the periodontal support tissue and is caused by microorganisms in the plaque biofilm. Periodontitis can lead to gingival atrophy and alveolar bone absorption. Inflammation control is an important treatment strategy for periodontitis. Rutin (rutin glyc...

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Bibliographic Details
Published in:Materials express 2020-12, Vol.10 (12), p.2048-2055
Main Authors: Xu, Xiongjun, Li, Chanxiu, Chen, Qiongyu, Sun, Wenjuan, Xiao, Feng, Chen, Qiang, Yuan, Jia
Format: Article
Language:English
Subjects:
Antioxidants
Atrophy
Bioavailability
Bioinformatics
Cytokines
Gingiva
Glycolic acid
Infectious diseases
Microorganisms
Nanoparticles
Nanosphere
Nanospheres
Periodontitis
Plga
Rutin
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Summary:Periodontitis is a chronic infectious disease of the periodontal support tissue and is caused by microorganisms in the plaque biofilm. Periodontitis can lead to gingival atrophy and alveolar bone absorption. Inflammation control is an important treatment strategy for periodontitis. Rutin (rutin glycoside of quercetin) has anti-inflammatory and antioxidant effects. It can inhibit oxidative stress and inflammatory reactions in model animals by regulating the MAPK pathway. However, the specific mechanism of Rutin in the treatment of periodontitis is not yet clear. Additionally, the bioavailability of Rutin requires improvement. Therefore, in this study, bioinformatics was used to predict the targets of Rutin, the differentially expressed genes were screened, and the related molecular pathways were verified by animal experiments. We found that local application of Rutin-loaded poly lactic-coglycolic acid nanospheres was beneficial to cytokine regulation. Rutin nanoparticles have therapeutic effects for periodontitis, which may be achieved by inhibiting the inflammatory reaction.
ISSN:2158-5849
2158-5857
DOI:10.1166/mex.2020.1867