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Therapeutic effect of rutin-loaded poly lactic-co-glycolic acid nanoparticles on gingiva of periodontitis rats
Periodontitis is a chronic infectious disease of the periodontal support tissue and is caused by microorganisms in the plaque biofilm. Periodontitis can lead to gingival atrophy and alveolar bone absorption. Inflammation control is an important treatment strategy for periodontitis. Rutin (rutin glyc...
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| Published in: | Materials express 2020-12, Vol.10 (12), p.2048-2055 |
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| Main Authors: | , , , , , , |
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| container_end_page | 2055 |
| container_issue | 12 |
| container_start_page | 2048 |
| container_title | Materials express |
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| creator | Xu, Xiongjun Li, Chanxiu Chen, Qiongyu Sun, Wenjuan Xiao, Feng Chen, Qiang Yuan, Jia |
| description | Periodontitis is a chronic infectious disease of the periodontal support tissue and is caused by microorganisms in the plaque biofilm. Periodontitis can lead to gingival atrophy and alveolar bone absorption. Inflammation control is an important treatment strategy for periodontitis.
Rutin (rutin glycoside of quercetin) has anti-inflammatory and antioxidant effects. It can inhibit oxidative stress and inflammatory reactions in model animals by regulating the MAPK pathway. However, the specific mechanism of Rutin in the treatment of periodontitis is not yet clear. Additionally,
the bioavailability of Rutin requires improvement. Therefore, in this study, bioinformatics was used to predict the targets of Rutin, the differentially expressed genes were screened, and the related molecular pathways were verified by animal experiments. We found that local application of
Rutin-loaded poly lactic-coglycolic acid nanospheres was beneficial to cytokine regulation. Rutin nanoparticles have therapeutic effects for periodontitis, which may be achieved by inhibiting the inflammatory reaction. |
| doi_str_mv | 10.1166/mex.2020.1867 |
| format | article |
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Rutin (rutin glycoside of quercetin) has anti-inflammatory and antioxidant effects. It can inhibit oxidative stress and inflammatory reactions in model animals by regulating the MAPK pathway. However, the specific mechanism of Rutin in the treatment of periodontitis is not yet clear. Additionally,
the bioavailability of Rutin requires improvement. Therefore, in this study, bioinformatics was used to predict the targets of Rutin, the differentially expressed genes were screened, and the related molecular pathways were verified by animal experiments. We found that local application of
Rutin-loaded poly lactic-coglycolic acid nanospheres was beneficial to cytokine regulation. Rutin nanoparticles have therapeutic effects for periodontitis, which may be achieved by inhibiting the inflammatory reaction.</description><identifier>ISSN: 2158-5849</identifier><identifier>EISSN: 2158-5857</identifier><identifier>DOI: 10.1166/mex.2020.1867</identifier><language>eng</language><publisher>26650 The Old Road, Suite 208, Valencia, California 91381-0751, USA: American Scientific Publishers</publisher><subject>Antioxidants ; Atrophy ; Bioavailability ; Bioinformatics ; Cytokines ; Gingiva ; Glycolic acid ; Infectious diseases ; Microorganisms ; Nanoparticles ; Nanosphere ; Nanospheres ; Periodontitis ; Plga ; Rutin</subject><ispartof>Materials express, 2020-12, Vol.10 (12), p.2048-2055</ispartof><rights>Copyright American Scientific Publishers Dec 2020</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-703e261a5c31a30b35c41d1e40645f12fa0a57796ef1b9f908e9d4d24e9fdb913</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925,53750</link.rule.ids></links><search><creatorcontrib>Xu, Xiongjun</creatorcontrib><creatorcontrib>Li, Chanxiu</creatorcontrib><creatorcontrib>Chen, Qiongyu</creatorcontrib><creatorcontrib>Sun, Wenjuan</creatorcontrib><creatorcontrib>Xiao, Feng</creatorcontrib><creatorcontrib>Chen, Qiang</creatorcontrib><creatorcontrib>Yuan, Jia</creatorcontrib><title>Therapeutic effect of rutin-loaded poly lactic-co-glycolic acid nanoparticles on gingiva of periodontitis rats</title><title>Materials express</title><description>Periodontitis is a chronic infectious disease of the periodontal support tissue and is caused by microorganisms in the plaque biofilm. Periodontitis can lead to gingival atrophy and alveolar bone absorption. Inflammation control is an important treatment strategy for periodontitis.
Rutin (rutin glycoside of quercetin) has anti-inflammatory and antioxidant effects. It can inhibit oxidative stress and inflammatory reactions in model animals by regulating the MAPK pathway. However, the specific mechanism of Rutin in the treatment of periodontitis is not yet clear. Additionally,
the bioavailability of Rutin requires improvement. Therefore, in this study, bioinformatics was used to predict the targets of Rutin, the differentially expressed genes were screened, and the related molecular pathways were verified by animal experiments. We found that local application of
Rutin-loaded poly lactic-coglycolic acid nanospheres was beneficial to cytokine regulation. Rutin nanoparticles have therapeutic effects for periodontitis, which may be achieved by inhibiting the inflammatory reaction.</description><subject>Antioxidants</subject><subject>Atrophy</subject><subject>Bioavailability</subject><subject>Bioinformatics</subject><subject>Cytokines</subject><subject>Gingiva</subject><subject>Glycolic acid</subject><subject>Infectious diseases</subject><subject>Microorganisms</subject><subject>Nanoparticles</subject><subject>Nanosphere</subject><subject>Nanospheres</subject><subject>Periodontitis</subject><subject>Plga</subject><subject>Rutin</subject><issn>2158-5849</issn><issn>2158-5857</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kM1LxDAQxYsouKwevQc8V5M06cdFEPELFvai5zCbTGqXblKbVNS_3tQVPTmXvCEvv5m8LDtj9IKxsrzc4fsFpzx1dVkdZAvOZJ3LWlaHv1o0x9lpCFuaSoqa1WKRuacXHGHAKXaaoLWoI_GWjKl3ee_BoCGD7z9IDzpZcu3ztv_Qvk920J0hDpwfYEx3PQbiHWk713ZvMFMGHDtvvItd7AIZIYaT7MhCH_D051xmz3e3TzcP-Wp9_3hzvcp1IUXMK1ogLxlIXTAo6KaQWjDDUNBSSMu4BQqyqpoSLds0tqE1NkYYLrCxZtOwYpmd77nD6F8nDFFt_TS6NFJxWUnOayqr5Lrau9LK6CL8mSAMaodqDlTR72K_gqv03VnMY9b_ADr9zZiTn4NXb4y69DIBGa1pqZigVBm0MPVRRRhV-6lCIn4B_bGKiw</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Xu, Xiongjun</creator><creator>Li, Chanxiu</creator><creator>Chen, Qiongyu</creator><creator>Sun, Wenjuan</creator><creator>Xiao, Feng</creator><creator>Chen, Qiang</creator><creator>Yuan, Jia</creator><general>American Scientific Publishers</general><scope>7SR</scope><scope>7TB</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>JG9</scope></search><sort><creationdate>20201201</creationdate><title>Therapeutic effect of rutin-loaded poly lactic-co-glycolic acid nanoparticles on gingiva of periodontitis rats</title><author>Xu, Xiongjun ; Li, Chanxiu ; Chen, Qiongyu ; Sun, Wenjuan ; Xiao, Feng ; Chen, Qiang ; Yuan, Jia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-703e261a5c31a30b35c41d1e40645f12fa0a57796ef1b9f908e9d4d24e9fdb913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antioxidants</topic><topic>Atrophy</topic><topic>Bioavailability</topic><topic>Bioinformatics</topic><topic>Cytokines</topic><topic>Gingiva</topic><topic>Glycolic acid</topic><topic>Infectious diseases</topic><topic>Microorganisms</topic><topic>Nanoparticles</topic><topic>Nanosphere</topic><topic>Nanospheres</topic><topic>Periodontitis</topic><topic>Plga</topic><topic>Rutin</topic><toplevel>online_resources</toplevel><creatorcontrib>Xu, Xiongjun</creatorcontrib><creatorcontrib>Li, Chanxiu</creatorcontrib><creatorcontrib>Chen, Qiongyu</creatorcontrib><creatorcontrib>Sun, Wenjuan</creatorcontrib><creatorcontrib>Xiao, Feng</creatorcontrib><creatorcontrib>Chen, Qiang</creatorcontrib><creatorcontrib>Yuan, Jia</creatorcontrib><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><jtitle>Materials express</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Xiongjun</au><au>Li, Chanxiu</au><au>Chen, Qiongyu</au><au>Sun, Wenjuan</au><au>Xiao, Feng</au><au>Chen, Qiang</au><au>Yuan, Jia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapeutic effect of rutin-loaded poly lactic-co-glycolic acid nanoparticles on gingiva of periodontitis rats</atitle><jtitle>Materials express</jtitle><date>2020-12-01</date><risdate>2020</risdate><volume>10</volume><issue>12</issue><spage>2048</spage><epage>2055</epage><pages>2048-2055</pages><issn>2158-5849</issn><eissn>2158-5857</eissn><abstract>Periodontitis is a chronic infectious disease of the periodontal support tissue and is caused by microorganisms in the plaque biofilm. Periodontitis can lead to gingival atrophy and alveolar bone absorption. Inflammation control is an important treatment strategy for periodontitis.
Rutin (rutin glycoside of quercetin) has anti-inflammatory and antioxidant effects. It can inhibit oxidative stress and inflammatory reactions in model animals by regulating the MAPK pathway. However, the specific mechanism of Rutin in the treatment of periodontitis is not yet clear. Additionally,
the bioavailability of Rutin requires improvement. Therefore, in this study, bioinformatics was used to predict the targets of Rutin, the differentially expressed genes were screened, and the related molecular pathways were verified by animal experiments. We found that local application of
Rutin-loaded poly lactic-coglycolic acid nanospheres was beneficial to cytokine regulation. Rutin nanoparticles have therapeutic effects for periodontitis, which may be achieved by inhibiting the inflammatory reaction.</abstract><cop>26650 The Old Road, Suite 208, Valencia, California 91381-0751, USA</cop><pub>American Scientific Publishers</pub><doi>10.1166/mex.2020.1867</doi><tpages>8</tpages></addata></record> |
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| language | eng |
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| source | IngentaConnect Journals |
| subjects | Antioxidants Atrophy Bioavailability Bioinformatics Cytokines Gingiva Glycolic acid Infectious diseases Microorganisms Nanoparticles Nanosphere Nanospheres Periodontitis Plga Rutin |
| title | Therapeutic effect of rutin-loaded poly lactic-co-glycolic acid nanoparticles on gingiva of periodontitis rats |
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