The loss of histone deacetylase 4 in macrophages exacerbates hepatic and adipose tissue inflammation in male but not in female mice with diet‐induced non‐alcoholic steatohepatitis

Epigenetic regulation in macrophages plays a crucial role in the inflammatory response of cells. We investigated the role of macrophage histone deacetylase 4 (HDAC4) in diet‐induced obesity and non‐alcoholic steatohepatitis using macrophage‐specific Hdac4 knockout mice (Hdac4MKO). Hdac4 floxed contr...

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Bibliographic Details
Published in:The Journal of pathology 2021-11, Vol.255 (3), p.319-329
Main Authors: Kang, Hyunju, Lee, Yoojin, Kim, Mi‐Bo, Hu, Siqi, Jang, Hyungryun, Park, Young‐Ki, Lee, Ji‐Young
Format: Article
Language:English
Subjects:
Adipose tissue
Adipose Tissue - pathology
Animals
Bone marrow
Cholesterol
Diet, High-Fat - adverse effects
Epigenetics
estrogen receptor α
Estrogen receptors
Fatty liver
Female
Females
Gene expression
High cholesterol diet
Histone deacetylase
histone deacetylase 4
Histone Deacetylases - metabolism
Inflammation
Inflammation - pathology
Lipopolysaccharides
Liver
Liver - pathology
macrophage
Macrophages
Macrophages - metabolism
Male
Mice
Mice, Knockout
Monocytes
Non-alcoholic Fatty Liver Disease - pathology
Obesity
Rodents
Sex Characteristics
sex difference
Spleen
Sucrose
Transcription activation
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