Low energy (0-12 eV) electron interaction with gas phase building blocks of DNA/RNA

We review recent results on dissociative electron attachment (DEA) to gas phase D-ribose, tetraacetyl-D-ribose (TAR) and dibutylphosphate (DBP), which serve as model compounds for the DNA or RNA backbone. New results are presented on negative ion formation in D-ribose probed by matrix-assisted laser...

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Bibliographic Details
Published in:Journal of physics. Conference series 2008-05, Vol.115 (1), p.012008
Main Authors: Bald, I, Kopyra, J, König, C, Flosadottir, H D, Ingolfsson, O, Illenberger, E
Format: Article
Language:English
Subjects:
Deoxyribonucleic acid
DNA
Electron attachment
Fragmentation
Ions
Mass spectrometry
Negative ions
Physics
Resonance
Ribonucleic acid
Ribose
RNA
Vapor phases
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Summary:We review recent results on dissociative electron attachment (DEA) to gas phase D-ribose, tetraacetyl-D-ribose (TAR) and dibutylphosphate (DBP), which serve as model compounds for the DNA or RNA backbone. New results are presented on negative ion formation in D-ribose probed by matrix-assisted laser desorption/ionisation time-of-flight (MALDI-TOF) mass spectrometry. The two methods reveal that the transient D-ribose anion R−# decomposes in the same way like the deprotonated D-ribose molecule [R-H]−, i.e. by abstraction of different numbers of water and formaldehyde units. In DEA the TNI R−# is generated at very low energies close to 0 eV most likely through a vibrational feshbach resonance. The fragmentation pattern and the characteristic resonances of D-ribose are preserved in TAR, where a furanose is bound to four acetyl groups. The presence of an acetyl group leads additionally to fragmentation through a shape resonance. Shape resonances were also observed in DBP, followed by C-O and P-O bond breaking.
ISSN:1742-6596
1742-6588
1742-6596
DOI:10.1088/1742-6596/115/1/012008