263 Helicobacter pylori infection in children with celiac disease

• Published in: Archives of disease in childhood 2021-10, Vol.106 (Suppl 2), p.A111-A112
• Main Authors: Orlova, Ekaterina, Valeria, Novikova, Natalia, Shapovalova, Olga, Gurina, Elena, Dementieva, Ksenia, Klikunova
• Format: Article
• Language: English
• Subjects: Abstracts; Antibodies; Autoimmune diseases; Autoimmunity; Biopsy; Celiac disease; Children; Helicobacter pylori; Hydrogen; Immunoglobulin A; Immunoglobulin G; Infections; Pediatrics; Potassium; Transglutaminase 2; Urease
• ISSN: 0003-9888; 1468-2044
• DOI: 10.1136/archdischild-2021-europaediatrics.263

Aim: to reveal the effect of H. pylori on course of celiac disease (CD) in children.Methods58 children with histologically confirmed CG and newly diagnosed CD were examined. Children were divided into two groups according to presence of H. pylori infection: the first group-12 H.pylori-positive and the second group – 46 H.pylori-negative subjects. All patients underwent histological examination of gastric and duodenal biopsies, histological verification of H. pylori infection and biopsy urease test. Tissue transglutaminase antibodies (tTG IgA, IgG) anti- H+/K+ ATPase and anti-intrinsic antibodies, were measured by ELISA.ResultsMean age of patients was 11.33 ±3.06 years in group1 and 10.38±1.43 years in group 2 (p=0.582). Manifestation of CD didn’t differ statistically significantly in groups. The prevalence of the classical form was 58.3% in group 1 and 66.7% group 2 (p=0.736); atypical CD 41.7% vs 31.1% (p=0.509). Moderate and severe epigastric pain was common in both groups: 50.0% vs 31.1% (p=0.309). Significantly elevated level of anti- tTG antibodies (>100RU/ml) was detected equally in groups: 33.3% vs 47.7% (p=0.516). The prevalence of elevated level of antiparietal antibodies in groups was the same: in group 1- anti- H+/K+ ATPase antibodies in 2 children and in 3 children in group 2; and anti-intrinsic antibodies in 1 person in group 1 as in group 2. Thus, 25% vs 8.7% (p=0,078).ConclusionThere are conflicting studies results regarding the association between H. pylori and CD. Whether Helicobacter pylori triggers, doesn’t affect or protects against CD is currently the subject of research. This study didn’t reveal any effects of H. pylori on course of celiac disease in children despite the fact, that H. pylori is suspected as possible trigger of autoimmunity.