The genetic symphony of human brain evolution

Because gradients in retinoic acid levels were present across cortical areas in all three species studied (despite there being lower overall levels in mice), the authors used mouse models to investigate the role of retinoic acid signalling in the development of features associated with the human PFC...

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Bibliographic Details
Published in:Nature (London) 2021-10, Vol.598 (7881), p.417-418
Main Authors: Wallace, Jenelle L, Pollen, Alex A
Format: Article
Language:English
Subjects:
Acids
Animal cognition
Animal models
Binding sites
Biological evolution
Brain
Enzymes
Evolution
Gene expression
Monkeys & apes
Nucleotide sequence
Retinoic acid
Signaling
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Summary:Because gradients in retinoic acid levels were present across cortical areas in all three species studied (despite there being lower overall levels in mice), the authors used mouse models to investigate the role of retinoic acid signalling in the development of features associated with the human PFC. Building on their observation that CBLN2 expression is increased by retinoic acid signalling, the authors examined putative CREs near this gene, and discovered one such DNA sequence that promotes gene expression - called an enhancer - and that is active during early PFC development. [...]at which points during primate evolution did these changes in cis- and trans-acting regulators occur?
ISSN:0028-0836
1476-4687
DOI:10.1038/d41586-021-02460-3