Construction of Function‐Oriented Core–Shell Nanostructures in Hydrogen‐Bonded Organic Frameworks for Near‐Infrared‐Responsive Bacterial Inhibition

• Published in: Angewandte Chemie International Edition 2021-12, Vol.60 (49), p.25701-25707
• Main Authors: Liu, Bai‐Tong, Pan, Xiao‐Hong, Zhang, Ding‐Yang, Wang, Rui, Chen, Jun‐Yu, Fang, Han‐Ru, Liu, Tian‐Fu
• Format: Article
• Language: English
• Subjects: Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; antimicrobials; Composite materials; Core-shell structure; core–shell composite; E coli; Energy transfer; Escherichia coli - drug effects; Heterostructures; Hydrogen Bonding; I.R. radiation; Imides - chemical synthesis; Imides - chemistry; Imides - pharmacology; Infrared Rays; Irradiation; Microbial Sensitivity Tests; Nanocomposites; Nanoparticles; Nanostructures - chemistry; Near infrared radiation; Particle Size; Perylene - analogs & derivatives; Perylene - chemical synthesis; Perylene - chemistry; Perylene - pharmacology; photodynamic; Photoresponse; Photosensitizing Agents - chemical synthesis; Photosensitizing Agents - chemistry; Photosensitizing Agents - pharmacology; photothermal; Porosity; resonance energy transfer; Ships; Surface Properties
• ISSN: 1433-7851; 1521-3773
• DOI: 10.1002/anie.202110028

Exploration of effective ways to integrate various functional species into hydrogen‐bonded organic frameworks (HOFs) is critically important for their applications but highly challenging. In this study, according to the “bottle‐around‐ship” strategy, core–shell heterostructure of upconversion nanoparticles (UCNPs) and HOFs was fabricated for the first time via a ligand‐grafting stepwise method. The UCNPs “core” can effectively upconvert near‐infrared (NIR) irradiation (980 nm) into visible light (540 nm and 653 nm), which further excites the perylenediimide‐based HOF “shell” through resonance energy transfer. In this way, the nanocomposite inherits the high porosity, excellent photothermal and photodynamic efficiency, NIR photoresponse from two parent materials, achieving intriguing NIR‐responsive bacterial inhibition toward Escherichia coli. This study may shed light on the design of functional HOF‐based composite materials, not only enriching the HOF library but also broadening the horizon of their potential applications. In this study, core–shell heterostructures of upconversion nanoparticles (UCNPs) and hydrogen‐bonded organic frameworks (HOFs) were fabricated via a stepwise ligand‐grafting method. The UCNP “core” can effectively upconvert near‐infrared (NIR) irradiation into visible ranges, which can further excite the HOF “shell” to achieve near‐infrared‐responsive photothermal and photodynamic bacterial inhibition.