Differential Circulating MicroRNA Expression in Age-Related Macular Degeneration

This study explored the expression of several miRNAs reported to be deregulated in age-related macular degeneration (AMD). Total RNA was isolated from sera from patients with dry AMD (n = 12), wet AMD (n = 14), and controls (n = 10). Forty-two previously investigated miRNAs were selected based on pu...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-11, Vol.22 (22), p.12321
Main Authors: ElShelmani, Hanan, Brennan, Ian, Kelly, David J., Keegan, David
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alzheimer's disease
Angiogenesis
Biomarkers
Biomarkers - blood
Case-Control Studies
Circulating MicroRNA - blood
Circulating MicroRNA - genetics
Circulating MicroRNA - isolation & purification
Female
Gene Expression
Gene Expression Regulation
Geographic Atrophy - blood
Geographic Atrophy - genetics
Humans
Hypoxia
Ischemia
Macular degeneration
Male
MicroRNAs
Middle Aged
Neurodegeneration
Oxidative stress
Real-Time Polymerase Chain Reaction - methods
Wet Macular Degeneration - blood
Wet Macular Degeneration - genetics
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