Impact of Lumen Occlusion on Outcomes in Locally Advanced Rectal Adenocarcinoma

Rectal cancer presenting with intestinal obstruction has historically been associated with poor outcomes. However, most of these studies were published before the neoadjuvant chemoradiation era. We intended to look for the outcomes of patients with rectal cancer presenting with and without luminal o...

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Bibliographic Details
Published in:Indian journal of surgery 2021-12, Vol.83 (6), p.1401-1406
Main Authors: Shinde, Rajesh S., Gupta, Amit, Patil, Prachi, Desouza, Ashwin, Ostwal, Vikas, Engineer, Reena, Saklani, Avanish
Format: Article
Language:English
Subjects:
Cancer patients
Cardiac Surgery
Care and treatment
Colonoscopy
Colorectal cancer
Comparative analysis
Gastrointestinal diseases
Intestinal obstruction
Medicine
Medicine & Public Health
Neurosurgery
Original Article
Patient outcomes
Pediatric Surgery
Plastic Surgery
Surgery
Thoracic Surgery
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Summary:Rectal cancer presenting with intestinal obstruction has historically been associated with poor outcomes. However, most of these studies were published before the neoadjuvant chemoradiation era. We intended to look for the outcomes of patients with rectal cancer presenting with and without luminal occlusion. One hundred eighty-nine consecutive patients, compliant with the treatment protocol from January 2013 to May 2014 were included in the study. They were classified as lumen-occluding or non-lumen-occluding based on colonoscopy, and outcomes were compared in the 2 groups. The two groups had similar demographic profiles. Median follow-up time of the study cohort was 5 years. The 5-year overall survival was 72.2% and 54.8% in the lumen non-occluding and lumen-occluding group, respectively. This difference was not statistically significant ( p –0.34). However, 5-year disease-free survival was 65.1% and 39.9% in the non-occluding group and lumen-occluding group, respectively ( p = 0.02). This difference in disease-free survival was not significant on multivariate analysis ( p –0.07). Lumen-occluding growths on colonoscopy are not associated with poor outcomes in today’s era.
ISSN:0972-2068
0973-9793
DOI:10.1007/s12262-020-02678-x