Synthesis, Characterization and Hyperthermic Evaluation of PEGylated Superparamagnetic MnFe2O4 Ferrite Nanoparticles for Cancer Therapeutics Applications

Poly(ethylene glycol) (PEG)‐coated superparamagnetic MnFe2O4 ferrite nanoparticles are of great interest for application in magnetic fluid hyperthermia (MFH) due to their heat generation capability in an external alternating magnetic field, besides biocompatibility, and surface properties. MFH has e...

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Bibliographic Details
Published in:Macromolecular symposia. 2021-12, Vol.400 (1), p.n/a
Main Authors: Kharat, Prashant B., Somvanshi, Sandeep B., Somwanshi, Saurabh B., Mopari, Anuja M.
Format: Article
Language:English
Subjects:
Bioaccumulation
Biocompatibility
Cancer
Chemical synthesis
Conjugation
Coupling (molecular)
Coupling agents
Ferrites
Folic acid
FT‐IR
Heat generation
Hyperthermia
Magnetic fields
Magnetic fluids
Magnetic properties
Magnetic saturation
modifications
morphology
Nanoparticles
Polyethylene glycol
Surface properties
Tumors
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Summary:Poly(ethylene glycol) (PEG)‐coated superparamagnetic MnFe2O4 ferrite nanoparticles are of great interest for application in magnetic fluid hyperthermia (MFH) due to their heat generation capability in an external alternating magnetic field, besides biocompatibility, and surface properties. MFH has emerged as a promising therapeutic approach for cancer treatment and is based on controlled heating tumor tissue through the accumulation of MnFe2O4 ferrite nanoparticles within cancer cells. In the present work, MnFe2O4 superparamagnetic ferrite nanoparticles via the chemical combustion method are synthesized. The preparation of PEGylated MnFe2O4 ferrite nanoparticles, which involves the attachment of such molecules at the surface, without the need for coupling agents or prior modification on the species involved. The conjugation of folate onto MnFe2O4 ferrite nanoparticles is confirmed by FTIR spectroscopy. The MnFe2O4 ferrite nanoparticles are colloidal stable. The obtained targeted PEGylated MnFe2O4 ferrite nanoparticles show superparamagnetic behavior with a saturation magnetization of 78.68 emu·g−1 at 300 K. Their specific absorption rate (SAR) ranged from 43.2 to 19.5 W g−1 in an alternating magnetic field of 5—20 kA m−1. The heat generated is sufficient to raise the sample temperature to the therapeutic range used in MFH establishing this system as promising candidates for use in MFH treatment.
ISSN:1022-1360
1521-3900
DOI:10.1002/masy.202100130