Diagnosis of Alzheimer's disease by analyzing the roughness of the retinal layers

Purpose Alzheimer’s Disease (AD) is the most common cause of dementia. Retinal thickness changes had been reported in different stages of the disease, being these changes a biomarker of AD progression. There is increasing evidence that thinned and thickened regions are interspersed throughout the re...

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Bibliographic Details
Published in:Acta ophthalmologica (Oxford, England) England), 2022-01, Vol.100 (S267), p.n/a
Main Authors: Salobrar‐Garcia, Elena, Jañez‐García, L., Bachtoula, O., López‐Cuenca, Inés, Elvira‐Hurtado, Lorena, Hoz, Rosa, Jose Salazar, Juan, Isabel Ramírez, Ana, Jañez‐Escalada, Luis, Manuel Ramírez, Jose
Format: Article
Language:English
Subjects:
Acuity
Alzheimer's disease
Biomarkers
Cognitive ability
Dementia disorders
Factor analysis
Inflammation
Neurodegenerative diseases
Retina
Statistics
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Summary:Purpose Alzheimer’s Disease (AD) is the most common cause of dementia. Retinal thickness changes had been reported in different stages of the disease, being these changes a biomarker of AD progression. There is increasing evidence that thinned and thickened regions are interspersed throughout the retinal layers of AD patients, resulting in the roughness of their bounding surfaces and thickness maps. The aim of this work is to prove the roughness of retinal layers, as assessed by the fractal dimension (FD) of their thickness maps, is an early biomarker of AD. Methods A complete ophthalmological exam and cognitive test (Mini Mental State Examination) was carried out in 24 healthy volunteers and 19 patients with mild AD. Total retinal thickness and retinal layers thickness were studied by optical coherence tomography (OCT) and thickness retinal maps were obtained. From the whole retinal area scanned on each subject only a central square region available from all sample subjects was kept for roughness analysis. In this square, the FD of the thickness map of each retinal layer was calculated as an index of its roughness. Results The FD of retinal layers is significantly higher (p 
ISSN:1755-375X
1755-3768
DOI:10.1111/j.1755-3768.2022.197