In vitro and in vivo antibacterial activity of graphene oxide-modified porous TiO2 coatings under 808-nm light irradiation

Bio-inertness and post-surgery infection on titanium (Ti) are the main causes of failure of biomedical implants in vivo. Near-infrared (NIR) photoactivated antibacterial therapy including photothermal and photodynamic therapies has attracted increasing attention due to the high bactericidal efficien...

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Bibliographic Details
Published in:Rare metals 2022-02, Vol.41 (2), p.540-545
Main Authors: Chai, Mao-Zhou, An, Mei-Wen, Zhang, Xiang-Yu, Chu, Paul-K.
Format: Article
Language:English
Subjects:
Biological activity
Biomaterials
Biomedical materials
Chemistry and Materials Science
Coatings
Energy
Graphene
Hyperthermia
Letter
Light irradiation
Materials Engineering
Materials Science
Metallic Materials
Nanoscale Science and Technology
Near infrared radiation
Oxidation
Physical Chemistry
Side effects
Surgical implants
Synergistic effect
Titanium
Titanium dioxide
Transplants & implants
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Summary:Bio-inertness and post-surgery infection on titanium (Ti) are the main causes of failure of biomedical implants in vivo. Near-infrared (NIR) photoactivated antibacterial therapy including photothermal and photodynamic therapies has attracted increasing attention due to the high bactericidal efficiency and little side effects. Although micro-arc oxidation (MAO) is an effective method to improve the biological activity of Ti implants, the porous TiO 2 coatings prepared by MAO do not respond to near-infrared (NIR) light to kill bacteria by the photothermal and photodynamic effects. In this work, graphene oxide (GO)-modified TiO 2 coatings (TiO 2 /GO) are prepared on Ti to improve the photothermal and photodynamic ability of the MAO coatings. The TiO 2 /GO coatings exhibit excellent antibacterial activity both in vitro and in vivo against Streptococcus mutans ( S. mutans ) under 808-nm NIR light irradiation due to the synergistic effects rendered by hyperthermia and reactive oxygen species (ROS). The NIR light-responsive antibacterial MAO coatings have large potential in combating implant-associated infections in clinical applications. Graphic abstract
ISSN:1001-0521
1867-7185
DOI:10.1007/s12598-021-01754-9