Robocasting and surface functionalization with highly bioactive glass of ZrO2 scaffolds for load bearing applications

This work is a proof of concept for making load bearing implants with osseointegration and bone bonding ability. Yttria‐stabilized zirconia (YSZ) scaffolds with a percentage of macro porosity of about 70% were fabricated by robocasting. Although a maximum solids volume fraction of 50 vol.% could be...

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Bibliographic Details
Published in:Journal of the American Ceramic Society 2022-03, Vol.105 (3), p.1753-1764
Main Authors: Gaddam, Anuraag, Brazete, Daniela S., Neto, Ana S., Nan, Bo, Fernandes, Hugo R., Ferreira, José M. F.
Format: Article
Language:English
Subjects:
alkali‐free glasses
bioactive glasses
Bioglass
Biological activity
Biomedical materials
Body fluids
bone
Compressive strength
Ethanol
Filaments
Glazing
Hydroxyapatite
In vitro methods and tests
Inks
Polyvinylpyrrolidone
Scaffolds
Sintering (powder metallurgy)
Surgical implants
Three dimensional printing
Tissue engineering
Yttria-stabilized zirconia
Yttrium oxide
Zirconium dioxide
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Summary:This work is a proof of concept for making load bearing implants with osseointegration and bone bonding ability. Yttria‐stabilized zirconia (YSZ) scaffolds with a percentage of macro porosity of about 70% were fabricated by robocasting. Although a maximum solids volume fraction of 50 vol.% could be achieved, the 3D‐printing process revealed to be more reliable when using inks with 48 vol.% solids. The sintered porous structures exhibited an average compressive strength of ~236 MPa. After some preliminary coating experiments, an ethanol slurry of fine bioactive glass (BG) particles (10 wt.%) stabilized with polyvinylpyrrolidone was used to deposit a uniform surface coating onto the filaments, followed by glazing at 850°C. The functionalized scaffolds showed a relatively uniform surface coverage by the bioactive glass. The results of in vitro testing by immersing the scaffolds in simulated body fluid (SBF) showed remarkable morphological surface changes and an extensive deposition of hydroxyapatite layer. The overall results demonstrate the viability of producing porous YSZ scaffolds with excellent bioactivity, which are promising for bone tissue engineering under load bearing applications.
ISSN:0002-7820
1551-2916
DOI:10.1111/jace.17869