SARS-CoV-2 spike engagement of ACE2 primes S2′ site cleavage and fusion initiation

The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in tremendous loss worldwide. Although viral spike (S) protein binding of angiotensin-converting enzyme 2 (ACE2) has been established, the functional consequences of the initial recept...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2022-01, Vol.119 (1), p.1-11, Article e2111199119
Main Authors: Yu, Shi, Zheng, Xu, Zhou, Bingjie, Li, Juan, Chen, Mengdan, Deng, Rong, Wong, Gary, Lavillette, Dimitri, Meng, Guangxun
Format: Article
Language:English
Subjects:
ACE2
Angiotensin
Angiotensin-converting enzyme 2
Angiotensin-Converting Enzyme 2 - chemistry
Angiotensin-Converting Enzyme 2 - metabolism
Animals
Binding
Biological Sciences
Cell Behavior
Cell fusion
Cell lines
Cellular Biology
Cleavage
Coronaviruses
COVID-19
COVID-19 - virology
Emerging diseases
HEK293 Cells
Host-Pathogen Interactions
Human health and pathology
Humans
Infections
Infectious diseases
Life Sciences
Membrane Fusion
Mice
Microbiology
Microbiology and Parasitology
Mutagenesis
Pandemics
Peptidyl-dipeptidase A
Protein Binding
Proteolysis
Pulmonology and respiratory tract
Receptors
Respiratory diseases
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Spike Glycoprotein, Coronavirus - chemistry
Spike Glycoprotein, Coronavirus - metabolism
Syncytia
Viral diseases
Virology
Virus Internalization
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