Atypical preeclampsia without underlying disease and elevated sFlt‐1/PlGF ratio

Atypical preeclampsia before 20 weeks of gestation without an underlying disease is very rare; however, the soluble Fms‐like tyrosine kinase 1/placental growth factor (sFlt‐1/PlGF) ratios remain unknown. Four pregnant women with no underlying disease, except for a history of childhood IgA vasculitis...

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Bibliographic Details
Published in:The journal of obstetrics and gynaecology research 2022-02, Vol.48 (2), p.471-476
Main Authors: Mimura, Kazuya, Tomimatsu, Takuji, Endo, Masayuki, Kimura, Tadashi
Format: Article
Language:English
Subjects:
atypical preeclampsia
Biomarkers
Children
Female
Gestation
Humans
Immunoglobulin A
Placenta Growth Factor
placental growth factor
Pre-eclampsia
Pre-Eclampsia - diagnosis
Preeclampsia
Pregnancy
Protein-tyrosine kinase
soluble fms‐like tyrosine kinase 1
Vascular Endothelial Growth Factor Receptor-1
Vasculitis
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Summary:Atypical preeclampsia before 20 weeks of gestation without an underlying disease is very rare; however, the soluble Fms‐like tyrosine kinase 1/placental growth factor (sFlt‐1/PlGF) ratios remain unknown. Four pregnant women with no underlying disease, except for a history of childhood IgA vasculitis, developed preeclampsia at 13, 14, 17, and 18 weeks of gestation with sFlt‐1/PlGF ratios of 1589, 1183, 500, and 1460 pg/mL, respectively. Their pregnancies were terminated, and they delivered within 2 weeks. All previously abnormal clinical findings normalized within 3 months. The sFlt‐1/PlGF ratios were elevated in the four patients with atypical preeclampsia without underlying disease before 20 weeks of gestation. A high sFlt‐1/PlGF ratio may be indicative of preeclampsia when no underlying disease is present in pregnancies of less than 20 weeks of gestation.
ISSN:1341-8076
1447-0756
DOI:10.1111/jog.15117