Oxygenated‐bacterial‐cellulose nanofibers with hydrogel, antimicrobial, and controlled oxygen release properties for rapid wound healing

The most effective approach for wound healing improvement is entrapping and controlling the oxygen in a biocompatible polymer matrix through introducing hydrogen peroxide. In the research, the bacterial cellulose (BC) layers were oxygenated as a safe and excellent hydrogel to accelerate the wound he...

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Bibliographic Details
Published in:Journal of applied polymer science 2022-04, Vol.139 (16), p.n/a
Main Authors: Fadakar Sarkandi, Aida, Montazer, Majid, Mahmoudi Rad, Mahnaz
Format: Article
Language:English
Subjects:
Biocompatibility
biomaterials
biomedical applications
biosynthesis of polymers
Cellulose
cellulose and other wood products
Cellulose fibers
Dissolved oxygen
Drying
Fungicides
Hydrogels
Hydrogen peroxide
Materials science
Mechanical properties
Nanofibers
Oxygenation
Polymers
Porosity
swelling
Thermodynamic properties
Water vapor
Wound healing
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Summary:The most effective approach for wound healing improvement is entrapping and controlling the oxygen in a biocompatible polymer matrix through introducing hydrogen peroxide. In the research, the bacterial cellulose (BC) layers were oxygenated as a safe and excellent hydrogel to accelerate the wound healing process. Indeed, the hydrogel‐containing hydrogen peroxide was obtained using the treatment of dry BC with 3% hydrogen peroxide for 5 h. The morphology, thermal behavior, crystalline and chemical structures, mechanical properties, water vapor permeability, degree of porosity, oxygen release, water holding capacity, and drying time of the treated layers were investigated. Furthermore, the calculated porosity showed about seven times more pore area. The dissolved oxygen results indicated the well‐trapped oxygen in BC with a prolonged‐release time of 20 days. Moreover, the 100% antibacterial and antifungal activities and excellent wound healing properties without cytotoxic effects specified the ability of BC to trap and release oxygen for efficient wound healing. Hence, the study introduces a functionalized naturally driven hydrogel layer with oxygen delivery, safe antimicrobial properties, and prolonged drying time.
ISSN:0021-8995
1097-4628
DOI:10.1002/app.51974