Analysis of Distribution and Grouping of MRI Characteristics of Age-Related Cerebral Microangiopathy

Small vessel disease (SVD) is the leading cause of vascular and cognitive impairment (CIs) mixed with neurodegeneration. MRI can shed light on SVD pathogenesis and progression mechanisms in vivo. The aim of our study is the assessment of heterogenity of MRI features (based on the STRIVE standard) in...

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Bibliographic Details
Published in:Human physiology 2021-12, Vol.47 (8), p.901-910
Main Authors: Kremneva, E. I., Zabitova, M. R., Shamtieva, K. V., Krotenkova, M. V., Dobrynina, L. A.
Format: Article
Language:English
Subjects:
Age
Atrophy
Basal ganglia
Biomedical and Life Sciences
Biomedicine
Brain injury
Cluster analysis
Cognitive ability
Human Physiology
Ischemia
Life Sciences
Magnetic resonance imaging
Neurodegeneration
Patients
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Summary:Small vessel disease (SVD) is the leading cause of vascular and cognitive impairment (CIs) mixed with neurodegeneration. MRI can shed light on SVD pathogenesis and progression mechanisms in vivo. The aim of our study is the assessment of heterogenity of MRI features (based on the STRIVE standard) in age-related SVD and its relation to disease progression mechanisms. 96 patients with age-related SVD (of different severities) (63 women; mean age, 60.6 ± 6.3 years) and 23 healthy volunteers (15 women; mean age, 58 ± 6 years) were examined. MRI scanning (3 T) for all participants included T2-WI, T1-WI, DWI, FLAIR, and SWI regimens with subsequent analysis of SVD brain lesions based on the STRIVE standards. STRIVE features were asessed using a four-point scale. The cluster analysis for Fazekas 3 patients showed two clusters of SVD MRI features. Group 1 had mostly periventricular WMHs, more lacunes, microbleeds, and brain atrophy. Group 2 did not have microbleeds and exhibited mostly juxtacortical WMH (Group 2-2) or posterior leucoaraiosis in periventricular WM with WM lacunes and enlarged perivascular spaces in the basal ganglia (Group 2-1). The combination of MRI features in each cluster probably reflects the predominance of ischemic and non-ischemic mechanisms of SVD. Our results provide evidence for different mechanisms of small brain vessels and brain parenchymal damage in SVD. Further studies are needed to see the clinical relevance.
ISSN:0362-1197
1608-3164
DOI:10.1134/S0362119721080119