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Effect of physical therapy on the oxidative homeostasis state in women with metabolic syndrome
Particular importances have pathological conditions, formation of which is based on a complex of metabolic disorders. The metabolic syndrome is a classic representative picture of such conditions. The current approach in the treatment of patients is based on the correction of body weight, impact on...
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Published in: | Journal of Physical Education and Sport 2021-10, Vol.21, p.3060-3067 |
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Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | Particular importances have pathological conditions, formation of which is based on a complex of metabolic disorders. The metabolic syndrome is a classic representative picture of such conditions. The current approach in the treatment of patients is based on the correction of body weight, impact on insulin resistance, normalization of blood pressure, achievement of the better metabolic control. Meanwhile, the therapeutic solutions are not always effective, and pharmacotherapy, especially aimed at a weight loss, does not give positive results. Common factor all components of the metabolic syndrome is oxidative stress, i.e. a condition which is characterized by increasing content of free radical molecules due to the imbalance between production and inactivation active forms of oxygen with cell damage. It is underlies a number of pathological processes such as inflammation, hypoxia, reperfusion of tissues and organ. Aim of research: to improve state of oxidative homeostasis in the patients with metabolic syndrome through application of physical therapy. Materials and methods. On the basis of medical centre for outpatient services for children and adults "Doctrine" (city Dnipro) 27 women with metabolic syndrome at the age of (50.1±1.9) years were examined. Metabolic syndrome is confirmed by increasing of a body mass index (BMI), waist circumference (WC) more than 80 cm, hyperglycemia, changes of the serum lipid profile, persistent arterial hypertension, reduced glucose tolerance, presence of insulin resistance according to HOMA-IR index. Results. The program is based on a phased application of aerobic exercise and training with weight loading and resistance during 16 weeks. The basic principles of the given program are the following: individuality of loads, specificity and reversibility. The implementation of proposed program had a significant positive effect, contributing to the weakening intensity processes of a free radical oxidation of lipids. Such results are possible due to the enhancement of protective properties of antioxidant protection system. Significant positive effect of treatment was established due to the antioxidant enzyme circulating ceruloplasmin, whose normalization occurred in 75.0% of patients. Its insufficiency was observed only in single cases. Normal catalase activity was observed in 2.9 times more frequently than before physical therapy. Primary enzyme activity was insufficient in a half of women. Finally, enzyme level was increased on |
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ISSN: | 2247-8051 2247-806X |
DOI: | 10.7752/jpes.2021.s5407 |