Effect of synthesis conditions on local atomic structure and properties of low-toxic maghemite nanoparticles for local magnetic hyperthermia in oncology

Low-toxic colloidal superparamagnetic iron oxide nanoparticles (SPIONs) for theranostic applications were obtained by microwave-assisted technique. Nanoparticles were synthesized by the hydrothermal method under different conditions. XANES, XRD, and XPS studies support the maghemite (γ-Fe 2 O 3 ) at...

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Published in:Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology 2022-02, Vol.24 (2), Article 25
Main Authors: Kuchma, Elena A., Zolotukhin, P. V., Belanova, A. A., Soldatov, M. A., Kozakov, A. T., Kubrin, S. P., Polozhentsev, O. E., Medvedev, P. V., Soldatov, Alexander V.
Format: Article
Language:English
Subjects:
Atomic structure
Cell culture
Characterization and Evaluation of Materials
Chemistry and Materials Science
Data analysis
Electronic structure
Ferric oxide
Hyperthermia
Inorganic Chemistry
Iron oxides
Lasers
Magnetic measurement
Magnetic properties
Materials Science
Mossbauer spectroscopy
Nanoparticles
Nanotechnology
Oncology
Optical Devices
Optics
Photonics
Physical Chemistry
Research Paper
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Summary:Low-toxic colloidal superparamagnetic iron oxide nanoparticles (SPIONs) for theranostic applications were obtained by microwave-assisted technique. Nanoparticles were synthesized by the hydrothermal method under different conditions. XANES, XRD, and XPS studies support the maghemite (γ-Fe 2 O 3 ) atomic and electronic structure of the nanoparticles. XANES data analysis reveals that nanoparticles have the structure reminiscent of the macroscopic maghemite. Mossbauer spectroscopy supports the γ-Fe 2 O 3 phase of the nanoparticles and vibration magnetometry study shows that the nanoparticles appear to be superparamagnetic. Nanoparticle shape and size were studied by TEM and DLS methods. It was shown that the nanoparticles do not exceed 20 nm. Also, the nanoparticles are found to be low-toxic and did not have significant effects on the viability of the HeLa cell culture. The obtained nanoparticles generated heat with the highest ILP value of 2.56 nHm 2 /kg and can be considered potential candidates as heat mediators for local magnetic hyperthermia in oncology. Graphical abstract
ISSN:1388-0764
1572-896X
DOI:10.1007/s11051-021-05393-0