Novel PEGylated ZnO nanoparticles with optimized Y dopant exhibiting PL imaging, PDT and CT contrast properties

[Display omitted] •Y-Doped ZnO exhibits enhanced photoluminescence and CT contrast.•Y-Doped ZnO has shown good biocompatibility in Rhabdomyosarcoma cell lines.•Y-doped ZnO NPs treated cancer cells exhibited greater phototoxicity than bare ZnO NPs.•Y-doped ZnO NPs are promising candidate for biomedic...

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Bibliographic Details
Published in:Materials letters 2022-05, Vol.315, p.131986, Article 131986
Main Authors: Hassan, Syed Mujtaba ul, Akram, Waseem, Saifullah, Adnan, Khurshid, Ahmat, Ali, Zahid, Shahzad, Faisal, Iqbal, Zafar, Ahmad, Jamil
Format: Article
Language:English
Subjects:
Biocompatibility
Biomaterials
Biomedical materials
Cell death
Computed tomography
Imaging
Materials science
Medical electronics
Medical imaging
Nanoparticles
Photodynamic therapy
Photoluminescence
Toxicity
Tumors
Yttrium
Zinc coatings
Zinc oxide
Zinc oxides
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Summary:[Display omitted] •Y-Doped ZnO exhibits enhanced photoluminescence and CT contrast.•Y-Doped ZnO has shown good biocompatibility in Rhabdomyosarcoma cell lines.•Y-doped ZnO NPs treated cancer cells exhibited greater phototoxicity than bare ZnO NPs.•Y-doped ZnO NPs are promising candidate for biomedical applications. The potential of yttrium doped, PEG coated, zinc oxide nanoparticles (Y-ZnO NPs) in biomedical imaging and tumor treatment is evaluated. These nanoparticles, synthesized by a simple one-step hydrothermal route, exhibit enhanced photoluminescence (maximum for 7 wt% Y-ZnO) with increased X-ray attenuation characteristics which are tunable in terms of doping concentrations (32.14 Hounsfield Units /mg/ml for 10 wt% Y-ZnO). Rhabdomyosarcoma (Rd) cell lines exhibited significantly low cytotoxicity when treated with prepared NPs. The Photocytotoxicity results showed that even at a low concentration an increase in cell death was observed owing to the Reactive Oxygen Species (ROS) generating capability of these nanoparticles. Thus, Y-doped ZnO NPs show high potential to be used in biomedical applications, such as bimodal imaging and treatment of tumors via Photodynamic Therapy (PDT).
ISSN:0167-577X
1873-4979
DOI:10.1016/j.matlet.2022.131986