Nickel‐Catalyzed Reductive Acylation of Carboxylic Acids with Alkyl Halides and N‐Hydroxyphthalimide Esters Enabled by Electrochemical Process

A sustainable Ni‐catalyzed reductive acylation reaction of carboxylic acids via an electrochemical pathway is presented, affording a variety of ketones as major products. The reaction proceeds at ambient temperature using unactivated alkyl halides and N‐hydroxyphthalimide (NHP) esters as coupling pa...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2022-04, Vol.364 (9), p.1526-1531
Main Authors: Zhou, Xiao, Guo, Lin, Zhang, Haoxiang, Xia, Raymond Yang, Yang, Chao, Xia, Wujiong
Format: Article
Language:English
Subjects:
Acylation
Ambient temperature
carboxylic acid
Carboxylic acids
electrochemistry
Esters
Halides
Ketones
nickel
reductive coupling
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Summary:A sustainable Ni‐catalyzed reductive acylation reaction of carboxylic acids via an electrochemical pathway is presented, affording a variety of ketones as major products. The reaction proceeds at ambient temperature using unactivated alkyl halides and N‐hydroxyphthalimide (NHP) esters as coupling partners, which exhibits several synthetic advantages, including mild conditions and convenience of amplification (58% yield for 6 mmol scale reaction).
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202200003