Spectral–Luminescent and Spectrophotometric Study of Molecular and Anionic Forms of N-Methyl Derivatives of 5-Fluorouracil in Aqueous Solutions

Spectrophotometric and fluorescent (FL) methods have been used to study solutions of N -methyl derivatives of 5-fluorouracil (FU): 1-methyl-5-fluorouracil (1M-FU), 3-methyl-5-fluorouracil (3M-FU), and 1,3-dimethyl-5-fluorouracil (1,3DM-FU) in neutral (pH 6.8) and alkaline (pH 11) aqueous media. Fluo...

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Bibliographic Details
Published in:High energy chemistry 2022, Vol.56 (3), p.158-162
Main Authors: Ostakhov, S. S., Abdrakhimova, G. S., Kayumova, R. R., Ivanov, S. P., Khursan, S. L.
Format: Article
Language:English
Subjects:
Aqueous solutions
Chemistry
Chemistry and Materials Science
Fluorescence
Photonics
Physical Chemistry
Spectrophotometry
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Summary:Spectrophotometric and fluorescent (FL) methods have been used to study solutions of N -methyl derivatives of 5-fluorouracil (FU): 1-methyl-5-fluorouracil (1M-FU), 3-methyl-5-fluorouracil (3M-FU), and 1,3-dimethyl-5-fluorouracil (1,3DM-FU) in neutral (pH 6.8) and alkaline (pH 11) aqueous media. Fluorescence parameters, such as FL spectrum and quantum yield (φ), of 1M-FU, 3M-FU, 1,3DM-FU, and their anionic forms were recorded for the first time. Bathofluoric shifts in the FL maxima and an increase in the FL quantum yields of these compounds compared to unsubstituted FU at pH 6.8 and pH 11 have been observed. Interpretation of the revealed features is presented.
ISSN:0018-1439
1608-3148
DOI:10.1134/S0018143922030080