N-Phosphorylation of daunorubicin—synthetic approaches and antiproliferative properties of the products

Synthetic approaches to daunorubicin derivatives containing azide and propargyl fragments were developed. A series of phosphonate and bisphosphonate derivatives (including those containing P–C–P fragments) were obtained by the methods of click chemistry and by direct amidation. The obtained compound...

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Published in:Medicinal chemistry research 2022-06, Vol.31 (6), p.1011-1025
Main Authors: Moiseeva, Aleksandra A., Artyushin, Oleg I., Anikina, Lada V., Klemenkova, Zinaida S., Brel, Valery K.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Chemical synthesis
Cytotoxicity
Daunorubicin
Fragments
Inorganic Chemistry
Medicinal Chemistry
Original Research
Pharmacology/Toxicology
Phosphonates
Phosphorylation
Toxicity
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description Synthetic approaches to daunorubicin derivatives containing azide and propargyl fragments were developed. A series of phosphonate and bisphosphonate derivatives (including those containing P–C–P fragments) were obtained by the methods of click chemistry and by direct amidation. The obtained compounds show small cytotoxicity not higher than that of parent daunorubicin. Graphical abstract
doi_str_mv 10.1007/s00044-022-02889-9
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subjects Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Chemical synthesis
Cytotoxicity
Daunorubicin
Fragments
Inorganic Chemistry
Medicinal Chemistry
Original Research
Pharmacology/Toxicology
Phosphonates
Phosphorylation
Toxicity
title N-Phosphorylation of daunorubicin—synthetic approaches and antiproliferative properties of the products
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