C/EBPβ/AEP signaling couples atherosclerosis to the pathogenesis of Alzheimer’s disease

Atherosclerosis (ATH) and Alzheimer’s disease (AD) are both age-dependent inflammatory diseases, associated with infiltrated macrophages and vascular pathology and overlapping molecules. C/EBPβ, an Aβ or inflammatory cytokine-activated transcription factor, and AEP (asparagine endopeptidase) are int...

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Bibliographic Details
Published in:	Molecular psychiatry 2022-07, Vol.27 (7), p.3034-3046
Main Authors:	Liao, Jianming, Chen, Guiqin, Liu, Xia, Wei, Zheng Zachory, Yu, Shan Ping, Chen, Qianxue, Ye, Keqiang
Format:	Article
Language:	English
Subjects:	14/63 631/337 631/378 64/60 82/80 Alzheimer Disease - metabolism Alzheimer's disease Animals Aorta Apolipoprotein E Arteriosclerosis Asparagine Atherosclerosis Atherosclerosis - complications Behavioral Sciences Biological Psychology Blood flow CCAAT-Enhancer-Binding Protein-beta - genetics CCAAT-Enhancer-Binding Protein-beta - metabolism Cerebral blood flow Cholesterol Cognitive ability Coronary vessels Cytokines Disease Models, Animal Endopeptidases High fat diet Inflammatory diseases Low density lipoprotein Macrophages Medicine Medicine & Public Health Mice Mice, Knockout, ApoE Neurodegenerative diseases Neurosciences Pathogenesis Pathology Pharmacotherapy Psychiatry Signal transduction
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