Wound-healing activity of Algerian Lavandula stoechas and Mentha pulegium extracts: from traditional use to scientific validation

The aim of the present study has been to evaluate the antioxidant, antimicrobial and wound healing activity of Algerian Lavandula stoechas and Mentha pulegium methanol extracts (LE and ME, respectively) in order to scientifically validate their traditional use. After a preliminary phytochemical scre...

Full description

Saved in:
Bibliographic Details
Published in:Plant biosystems 2022-03, Vol.156 (2), p.427-439
Main Authors: Baali, Faiza, Boumerfeg, Sabah, Boudjelal, Amel, Denaro, Marcella, Ginestra, Giovanna, Baghiani, Abderrahmane, Righi, Nadjat, Deghima, Amirouche, Benbacha, Faycel, Smeriglio, Antonella, Trombetta, Domenico
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
Antimicrobial activity
Antimicrobial agents
antioxidant activity
Antioxidants
Flavones
Flavonols
Lavandula stoechas
Lavandula stoechas L
Mentha pulegium
Mentha pulegium L
Ointments
Phenolic acids
Phenols
Rosmarinic acid
Wound healing
wound-healing activity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of the present study has been to evaluate the antioxidant, antimicrobial and wound healing activity of Algerian Lavandula stoechas and Mentha pulegium methanol extracts (LE and ME, respectively) in order to scientifically validate their traditional use. After a preliminary phytochemical screening, a polyphenol profile characterization was carried out by RP-LC-DAD-ESI-MS/MS analysis. Antioxidant activity was evaluated by different in vitro assays such as DPPH, TEAC, FRAP and ORAC whereas antimicrobial activity was carried out against representative standard ATCC and clinical Gram-positive and Gram-negative strains as well as against Candida albicans. The wound healing activity of ointments containing 5% and 10% of LE and ME was investigated on Wistar albino rats. Different polyphenol classess (flavones, flavonols and phenolic acids) were identified with rosmarinic acid that was the most abundant compound in both extracts (5658.40 and 1201.35 mg/100 g of LE and ME, respectively). LE and ME have strong antioxidant activity, whereas they showed antimicrobial activity only against S. aureus. However, both 5% and 10% LE and ME ointments significantly accelerated the wound healing process in comparison with negative control, providing a scientific rationale for the traditional use of L. stoechas and M. pulegium aerial parts in the treatment of wounds.
ISSN:1126-3504
1724-5575
DOI:10.1080/11263504.2020.1869117