Synthesis of 3-(Organyloxymethyl)oxazolidines

The condensation/heterocyclization of 2-aminoethanol with formaldehyde and various alcohols afforded 3-(organyloxymethyl)-1,3-oxazolidines. Their yields depended on the nature of the hydroxy compound and increased in parallel with its size. 3,3′-Methylenebis(1,3-oxazolidine) was formed as by-product...

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Bibliographic Details
Published in:Russian journal of organic chemistry 2022-06, Vol.58 (6), p.800-804
Main Authors: Farzaliev, V. M., Abbasova, M. T., Soltanova, Z. K., Safarova, L. R.
Format: Article
Language:English
Subjects:
Alcohols
Chemistry
Chemistry and Materials Science
Condensates
Formaldehyde
NMR
Nuclear magnetic resonance
Organic Chemistry
Oxazolidine
Synthesis
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Summary:The condensation/heterocyclization of 2-aminoethanol with formaldehyde and various alcohols afforded 3-(organyloxymethyl)-1,3-oxazolidines. Their yields depended on the nature of the hydroxy compound and increased in parallel with its size. 3,3′-Methylenebis(1,3-oxazolidine) was formed as by-product; it was also synthesized independently by the condensation of 2-aminoethanol with formaldehyde at a ratio of 2:3. Physico­chemical characteristics and 13 C NMR spectra of the synthesized compounds are given. NMR signals were assigned using 13 C–{ 1 H} heteronuclear double-resonance technique.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428022060069