Detection of maternal carriers of common α-thalassemia deletions from cell-free DNA

α-Thalassemia is a common inherited blood disorder manifested mainly by the deletions of α-globin genes. In geographical areas with high carrier frequencies, screening of α-thalassemia carrier state is therefore of vital importance. This study presents a novel method for identifying female carriers...

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Published in:	Scientific reports 2022-08, Vol.12 (1), p.13581-9, Article 13581
Main Authors:	Doan, Phuoc-Loc, Nguyen, Duy-Anh, Le, Quang Thanh, Hoang, Diem-Tuyet Thi, Nguyen, Huu Du, Nguyen, Canh Chuong, Doan, Kim Phuong Thi, Tran, Nhat Thang, Ha, Thi Minh Thi, Trinh, Thu Huong Nhat, Nguyen, Van Thong, Bui, Chi Thuong, Lai, Ngoc-Diep Thi, Duong, Thanh Hien, Mai, Hai-Ly, Huynh, Pham-Uyen Vinh, Huynh, Thu Thanh Thi, Le, Quang Vinh, Vo, Thanh Binh, Dao, Thi Hong-Thuy, Vo, Phuong Anh, Le, Duy-Khang Nguyen, Tran, Ngoc Nhu Thi, Tran, Quynh Nhu Thi, Van, Yen-Linh Thi, Tran, Huyen-Trang Thi, Nguyen, Hoai Thi, Nguyen, Phuong-Uyen, Do, Thanh-Thuy Thi, Truong, Dinh-Kiet, Tang, Hung Sang, Cao, Ngoc-Phuong Thi, Lam, Tuan-Thanh, Tran, Le Son, Nguyen, Hoai-Nghia, Giang, Hoa, Phan, Minh-Duy
Format:	Article
Language:	English
Subjects:	631/114 631/208 631/61 692/699 alpha-Globins - genetics alpha-Thalassemia - diagnosis alpha-Thalassemia - genetics beta-Thalassemia - genetics Blood diseases Cell-Free Nucleic Acids China Female Fetuses Genotype Genotypes Humanities and Social Sciences Humans multidisciplinary Mutation Polymerase Chain Reaction - methods Pregnancy Science Science (multidisciplinary) Thalassemia
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