Encapsulation of curcumin in gliadin-pectin in a core–shell nanostructure for efficient delivery of curcumin to cancer cells in vitro

Curcumin, as a bioactive compound, has shown promising activity in cancer treatment, although having poor water solubility and bioavailability. Here, gliadin was extracted from wheat gluten and combined with pectin to encapsulate curcumin through an antisolvent precipitation method to enhance its bi...

Full description

Saved in:
Bibliographic Details
Published in:Colloid and polymer science 2022-09, Vol.300 (9), p.1063-1073
Main Authors: Banaee, Fatemeh, Poureini, Fatemeh, Mohammadi, Maedeh, Najafpour, Ghasem D., Moghadamnia, Ali Akbar
Format: Article
Language:English
Subjects:
Bioavailability
Biodegradable materials
Cancer
Cancer therapies
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Citrus fruits
Complex Fluids and Microfluidics
Core-shell structure
Cytotoxicity
Efficiency
Encapsulation
Ethanol
Food Science
Gliadin
Gluten
Nanocomposites
Nanoparticles
Nanotechnology and Microengineering
Original Contribution
Particle size
Pectin
Pharmaceuticals
Physical Chemistry
Polymer Sciences
Polymers
Proteins
Soft and Granular Matter
Spherical shells
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Curcumin, as a bioactive compound, has shown promising activity in cancer treatment, although having poor water solubility and bioavailability. Here, gliadin was extracted from wheat gluten and combined with pectin to encapsulate curcumin through an antisolvent precipitation method to enhance its bioavailability. The curcumin-gliadin-pectin (Cur-G-P) nanocomposite was characterized by DLS, FTIR, XRD, AFM, TGA-DTG, and TEM analyses. Under the optimum synthesis condition (pH = 4.5 and protein content of 3.2 w/v%), average particle size, PDI, and ζ-potential of the nanocomposite were 97 nm, 0.29, and − 23 mV; the curcumin encapsulation efficiency and nanocomposite particle yield were 75 and 92%, respectively. The developed core–shell spherical nanocomposite was pH-sensitive and had a high curcumin release of 87% within 240 min under acidic pH. Furthermore, the encapsulated curcumin showed cytotoxic effects against MCF7 and Saos2 cell lines up to 80.02 and 78.06%, respectively. Conclusively, Cur-G-P can be a promising nanocomposite for cancer treatment studies. Graphical Abstract
ISSN:0303-402X
1435-1536
DOI:10.1007/s00396-022-04998-8