Copper-catalyzed direct decarboxylative fluorosulfonylation of aliphatic carboxylic acids

Sulfonyl fluorides are emerging as key structural motifs in organic synthesis, medicinal chemistry, and materials science. Herein we report two efficient and complementary methods for direct decarboxylative fluorosulfonylation of carboxylic acids by the merging of copper catalysis with different N -...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2022-08, Vol.58 (67), p.949-9412
Main Authors: Yi, Ji-Tao, Zhou, Xiang, Chen, Qi-Long, Chen, Zhi-Da, Lu, Gui, Weng, Jiang
Format: Article
Language:English
Subjects:
Carboxylic acids
Chemical synthesis
Copper
Fluorides
Materials science
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Summary:Sulfonyl fluorides are emerging as key structural motifs in organic synthesis, medicinal chemistry, and materials science. Herein we report two efficient and complementary methods for direct decarboxylative fluorosulfonylation of carboxylic acids by the merging of copper catalysis with different N -centered HAT regents. A wide range of structurally diverse sulfonyl fluorides was readily accessed from primary, secondary, and tertiary carboxylic acids in a single step under mild conditions. Herein we report two complementary methods for direct decarboxylative fluorosulfonylation of carboxylic acids by the merging of copper catalysis with different N -centered HAT regents.
ISSN:1359-7345
1364-548X
DOI:10.1039/d2cc03221j