Respiratory distress syndrome in preterm infants of less than 32 weeks: What difference does giving 100 or 200mg/kg of exogenous surfactant make?

• Published in: Pediatric pulmonology 2022-09, Vol.57 (9), p.2067-2073
• Main Authors: Lanciotti, Lucia, Correani, Alessio, Pasqualini, Matteo, Antognoli, Luca, Dell'Orto, Valentina G, Giorgetti, Chiara, Colombo, Sara, Palazzi, Maria L, Rondina, Clementina, Burattini, Ilaria, Carnielli, Virgilio P
• Format: Article
• Language: English
• Subjects: Newborn babies; Premature babies; Respiratory distress syndrome; Surfactants
• ISSN: 8755-6863; 1099-0496
• DOI: 10.1002/ppul.25979

BackgroundSurfactant dosing and effective delivery could affect continuous positive airways pressure (CPAP)‐failure. Nevertheless, information on exogenous surfactant dosing with current administration methods is limited.ObjectiveTo describe the effect of 100 or 200 mg/kg of surfactant as first‐line treatment of respiratory distress syndrome in preterm infants of less than 32 weeks gestation.Study DesignA retrospective single‐center cohort study comparing two epochs, before and after switching from 100 to 200 mg/kg surfactant therapy.ResultsSix hundred and fifty‐eight of the 1615 infants of less than 32 weeks were treated with surfactant: 282 received 100 mg/kg (S‐100) and 376 received 200 mg/kg (S‐200). There were no differences between S‐100 and S‐200 in perinatal data including prenatal corticosteroids, medication use, age at first surfactant administration and respiratory severity before surfactant.The S‐200 vs. S‐100 had fewer retreatments (17.0% vs. 47.2%, p