Respiratory distress syndrome in preterm infants of less than 32 weeks: What difference does giving 100 or 200mg/kg of exogenous surfactant make?

BackgroundSurfactant dosing and effective delivery could affect continuous positive airways pressure (CPAP)‐failure. Nevertheless, information on exogenous surfactant dosing with current administration methods is limited.ObjectiveTo describe the effect of 100 or 200 mg/kg of surfactant as first‐line...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric pulmonology 2022-09, Vol.57 (9), p.2067-2073
Main Authors: Lanciotti, Lucia, Correani, Alessio, Pasqualini, Matteo, Antognoli, Luca, Dell'Orto, Valentina G, Giorgetti, Chiara, Colombo, Sara, Palazzi, Maria L, Rondina, Clementina, Burattini, Ilaria, Carnielli, Virgilio P
Format: Article
Language:English
Subjects:
Newborn babies
Premature babies
Respiratory distress syndrome
Surfactants
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 2073
container_issue 9
container_start_page 2067
container_title Pediatric pulmonology
container_volume 57
creator Lanciotti, Lucia
Correani, Alessio
Pasqualini, Matteo
Antognoli, Luca
Dell'Orto, Valentina G
Giorgetti, Chiara
Colombo, Sara
Palazzi, Maria L
Rondina, Clementina
Burattini, Ilaria
Carnielli, Virgilio P
description BackgroundSurfactant dosing and effective delivery could affect continuous positive airways pressure (CPAP)‐failure. Nevertheless, information on exogenous surfactant dosing with current administration methods is limited.ObjectiveTo describe the effect of 100 or 200 mg/kg of surfactant as first‐line treatment of respiratory distress syndrome in preterm infants of less than 32 weeks gestation.Study DesignA retrospective single‐center cohort study comparing two epochs, before and after switching from 100 to 200 mg/kg surfactant therapy.ResultsSix hundred and fifty‐eight of the 1615 infants of less than 32 weeks were treated with surfactant: 282 received 100 mg/kg (S‐100) and 376 received 200 mg/kg (S‐200). There were no differences between S‐100 and S‐200 in perinatal data including prenatal corticosteroids, medication use, age at first surfactant administration and respiratory severity before surfactant.The S‐200 vs. S‐100 had fewer retreatments (17.0% vs. 47.2%, p 
doi_str_mv 10.1002/ppul.25979
format article
fullrecord <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_journals_2704843788</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2704843788</sourcerecordid><originalsourceid>FETCH-proquest_journals_27048437883</originalsourceid><addsrcrecordid>eNqNjs1OwzAQhC0EEuHnwhOsxDmt8x9z4YBAPSMkjpXVrNM0iR12baCPwRvjSjwApxlpRt-MEHeZXGVS5utlCdMqr1SjzkSSSaVSWar6XCRtU1Vp3dbFpbhiPkgZM5Ul4ucVeRlIe0dH6Ab2hMzAR9uRmxEGCwuhR5qjNdp6BmdgOnX8XlsocvhCHPkB3vfaR4AxSGh3CJ1Dhn74HGwP8Ro4glzKuV-P_QmB365H60LcCmT0zkc2zHrExxtxYfTEePun1-L-5fntaZMu5D4Cst8eXCAbo23eyLIti6Zti_-1fgFBvlvF</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2704843788</pqid></control><display><type>article</type><title>Respiratory distress syndrome in preterm infants of less than 32 weeks: What difference does giving 100 or 200mg/kg of exogenous surfactant make?</title><source>Wiley-Blackwell Read &amp; Publish Collection</source><creator>Lanciotti, Lucia ; Correani, Alessio ; Pasqualini, Matteo ; Antognoli, Luca ; Dell'Orto, Valentina G ; Giorgetti, Chiara ; Colombo, Sara ; Palazzi, Maria L ; Rondina, Clementina ; Burattini, Ilaria ; Carnielli, Virgilio P</creator><creatorcontrib>Lanciotti, Lucia ; Correani, Alessio ; Pasqualini, Matteo ; Antognoli, Luca ; Dell'Orto, Valentina G ; Giorgetti, Chiara ; Colombo, Sara ; Palazzi, Maria L ; Rondina, Clementina ; Burattini, Ilaria ; Carnielli, Virgilio P</creatorcontrib><description>BackgroundSurfactant dosing and effective delivery could affect continuous positive airways pressure (CPAP)‐failure. Nevertheless, information on exogenous surfactant dosing with current administration methods is limited.ObjectiveTo describe the effect of 100 or 200 mg/kg of surfactant as first‐line treatment of respiratory distress syndrome in preterm infants of less than 32 weeks gestation.Study DesignA retrospective single‐center cohort study comparing two epochs, before and after switching from 100 to 200 mg/kg surfactant therapy.ResultsSix hundred and fifty‐eight of the 1615 infants of less than 32 weeks were treated with surfactant: 282 received 100 mg/kg (S‐100) and 376 received 200 mg/kg (S‐200). There were no differences between S‐100 and S‐200 in perinatal data including prenatal corticosteroids, medication use, age at first surfactant administration and respiratory severity before surfactant.The S‐200 vs. S‐100 had fewer retreatments (17.0% vs. 47.2%, p &lt; 0.001) and a shorter duration of oxygen therapy and mechanical ventilation (315 vs. 339 h, p = 0.018; 37 vs. 118 h, p = 0.000, respectively). There was no difference in postnatal corticosteroid use (S‐200 10.0% vs. S‐100 11.0%, p = 0.361). Bronchopulmonary dysplasia (BPD) was significantly lower in S‐200 vs. S‐100 when comparing either the 4 and 6‐year periods before and after the dose switch (29.4% vs. 15.7%, p = 0.003, and 18.7% vs. 27.3%, p = 0.024, respectively)ConclusionsThe switch from 100 to 200 mg/kg was associated with a marked reduction in the need for surfactant redosing, respiratory support, and BPD. This information could be important when designing a study in the modern era of less invasive administration as surfactant dosing and its effective delivery may affect the outcome.</description><identifier>ISSN: 8755-6863</identifier><identifier>EISSN: 1099-0496</identifier><identifier>DOI: 10.1002/ppul.25979</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc</publisher><subject>Newborn babies ; Premature babies ; Respiratory distress syndrome ; Surfactants</subject><ispartof>Pediatric pulmonology, 2022-09, Vol.57 (9), p.2067-2073</ispartof><rights>2022. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Lanciotti, Lucia</creatorcontrib><creatorcontrib>Correani, Alessio</creatorcontrib><creatorcontrib>Pasqualini, Matteo</creatorcontrib><creatorcontrib>Antognoli, Luca</creatorcontrib><creatorcontrib>Dell'Orto, Valentina G</creatorcontrib><creatorcontrib>Giorgetti, Chiara</creatorcontrib><creatorcontrib>Colombo, Sara</creatorcontrib><creatorcontrib>Palazzi, Maria L</creatorcontrib><creatorcontrib>Rondina, Clementina</creatorcontrib><creatorcontrib>Burattini, Ilaria</creatorcontrib><creatorcontrib>Carnielli, Virgilio P</creatorcontrib><title>Respiratory distress syndrome in preterm infants of less than 32 weeks: What difference does giving 100 or 200mg/kg of exogenous surfactant make?</title><title>Pediatric pulmonology</title><description>BackgroundSurfactant dosing and effective delivery could affect continuous positive airways pressure (CPAP)‐failure. Nevertheless, information on exogenous surfactant dosing with current administration methods is limited.ObjectiveTo describe the effect of 100 or 200 mg/kg of surfactant as first‐line treatment of respiratory distress syndrome in preterm infants of less than 32 weeks gestation.Study DesignA retrospective single‐center cohort study comparing two epochs, before and after switching from 100 to 200 mg/kg surfactant therapy.ResultsSix hundred and fifty‐eight of the 1615 infants of less than 32 weeks were treated with surfactant: 282 received 100 mg/kg (S‐100) and 376 received 200 mg/kg (S‐200). There were no differences between S‐100 and S‐200 in perinatal data including prenatal corticosteroids, medication use, age at first surfactant administration and respiratory severity before surfactant.The S‐200 vs. S‐100 had fewer retreatments (17.0% vs. 47.2%, p &lt; 0.001) and a shorter duration of oxygen therapy and mechanical ventilation (315 vs. 339 h, p = 0.018; 37 vs. 118 h, p = 0.000, respectively). There was no difference in postnatal corticosteroid use (S‐200 10.0% vs. S‐100 11.0%, p = 0.361). Bronchopulmonary dysplasia (BPD) was significantly lower in S‐200 vs. S‐100 when comparing either the 4 and 6‐year periods before and after the dose switch (29.4% vs. 15.7%, p = 0.003, and 18.7% vs. 27.3%, p = 0.024, respectively)ConclusionsThe switch from 100 to 200 mg/kg was associated with a marked reduction in the need for surfactant redosing, respiratory support, and BPD. This information could be important when designing a study in the modern era of less invasive administration as surfactant dosing and its effective delivery may affect the outcome.</description><subject>Newborn babies</subject><subject>Premature babies</subject><subject>Respiratory distress syndrome</subject><subject>Surfactants</subject><issn>8755-6863</issn><issn>1099-0496</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNqNjs1OwzAQhC0EEuHnwhOsxDmt8x9z4YBAPSMkjpXVrNM0iR12baCPwRvjSjwApxlpRt-MEHeZXGVS5utlCdMqr1SjzkSSSaVSWar6XCRtU1Vp3dbFpbhiPkgZM5Ul4ucVeRlIe0dH6Ab2hMzAR9uRmxEGCwuhR5qjNdp6BmdgOnX8XlsocvhCHPkB3vfaR4AxSGh3CJ1Dhn74HGwP8Ro4glzKuV-P_QmB365H60LcCmT0zkc2zHrExxtxYfTEePun1-L-5fntaZMu5D4Cst8eXCAbo23eyLIti6Zti_-1fgFBvlvF</recordid><startdate>20220901</startdate><enddate>20220901</enddate><creator>Lanciotti, Lucia</creator><creator>Correani, Alessio</creator><creator>Pasqualini, Matteo</creator><creator>Antognoli, Luca</creator><creator>Dell'Orto, Valentina G</creator><creator>Giorgetti, Chiara</creator><creator>Colombo, Sara</creator><creator>Palazzi, Maria L</creator><creator>Rondina, Clementina</creator><creator>Burattini, Ilaria</creator><creator>Carnielli, Virgilio P</creator><general>Wiley Subscription Services, Inc</general><scope>K9.</scope></search><sort><creationdate>20220901</creationdate><title>Respiratory distress syndrome in preterm infants of less than 32 weeks: What difference does giving 100 or 200mg/kg of exogenous surfactant make?</title><author>Lanciotti, Lucia ; Correani, Alessio ; Pasqualini, Matteo ; Antognoli, Luca ; Dell'Orto, Valentina G ; Giorgetti, Chiara ; Colombo, Sara ; Palazzi, Maria L ; Rondina, Clementina ; Burattini, Ilaria ; Carnielli, Virgilio P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_27048437883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Newborn babies</topic><topic>Premature babies</topic><topic>Respiratory distress syndrome</topic><topic>Surfactants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lanciotti, Lucia</creatorcontrib><creatorcontrib>Correani, Alessio</creatorcontrib><creatorcontrib>Pasqualini, Matteo</creatorcontrib><creatorcontrib>Antognoli, Luca</creatorcontrib><creatorcontrib>Dell'Orto, Valentina G</creatorcontrib><creatorcontrib>Giorgetti, Chiara</creatorcontrib><creatorcontrib>Colombo, Sara</creatorcontrib><creatorcontrib>Palazzi, Maria L</creatorcontrib><creatorcontrib>Rondina, Clementina</creatorcontrib><creatorcontrib>Burattini, Ilaria</creatorcontrib><creatorcontrib>Carnielli, Virgilio P</creatorcontrib><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><jtitle>Pediatric pulmonology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lanciotti, Lucia</au><au>Correani, Alessio</au><au>Pasqualini, Matteo</au><au>Antognoli, Luca</au><au>Dell'Orto, Valentina G</au><au>Giorgetti, Chiara</au><au>Colombo, Sara</au><au>Palazzi, Maria L</au><au>Rondina, Clementina</au><au>Burattini, Ilaria</au><au>Carnielli, Virgilio P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Respiratory distress syndrome in preterm infants of less than 32 weeks: What difference does giving 100 or 200mg/kg of exogenous surfactant make?</atitle><jtitle>Pediatric pulmonology</jtitle><date>2022-09-01</date><risdate>2022</risdate><volume>57</volume><issue>9</issue><spage>2067</spage><epage>2073</epage><pages>2067-2073</pages><issn>8755-6863</issn><eissn>1099-0496</eissn><abstract>BackgroundSurfactant dosing and effective delivery could affect continuous positive airways pressure (CPAP)‐failure. Nevertheless, information on exogenous surfactant dosing with current administration methods is limited.ObjectiveTo describe the effect of 100 or 200 mg/kg of surfactant as first‐line treatment of respiratory distress syndrome in preterm infants of less than 32 weeks gestation.Study DesignA retrospective single‐center cohort study comparing two epochs, before and after switching from 100 to 200 mg/kg surfactant therapy.ResultsSix hundred and fifty‐eight of the 1615 infants of less than 32 weeks were treated with surfactant: 282 received 100 mg/kg (S‐100) and 376 received 200 mg/kg (S‐200). There were no differences between S‐100 and S‐200 in perinatal data including prenatal corticosteroids, medication use, age at first surfactant administration and respiratory severity before surfactant.The S‐200 vs. S‐100 had fewer retreatments (17.0% vs. 47.2%, p &lt; 0.001) and a shorter duration of oxygen therapy and mechanical ventilation (315 vs. 339 h, p = 0.018; 37 vs. 118 h, p = 0.000, respectively). There was no difference in postnatal corticosteroid use (S‐200 10.0% vs. S‐100 11.0%, p = 0.361). Bronchopulmonary dysplasia (BPD) was significantly lower in S‐200 vs. S‐100 when comparing either the 4 and 6‐year periods before and after the dose switch (29.4% vs. 15.7%, p = 0.003, and 18.7% vs. 27.3%, p = 0.024, respectively)ConclusionsThe switch from 100 to 200 mg/kg was associated with a marked reduction in the need for surfactant redosing, respiratory support, and BPD. This information could be important when designing a study in the modern era of less invasive administration as surfactant dosing and its effective delivery may affect the outcome.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/ppul.25979</doi></addata></record>
fulltext fulltext
identifier ISSN: 8755-6863
ispartof Pediatric pulmonology, 2022-09, Vol.57 (9), p.2067-2073
issn 8755-6863
1099-0496
language eng
recordid cdi_proquest_journals_2704843788
source Wiley-Blackwell Read & Publish Collection
subjects Newborn babies
Premature babies
Respiratory distress syndrome
Surfactants
title Respiratory distress syndrome in preterm infants of less than 32 weeks: What difference does giving 100 or 200mg/kg of exogenous surfactant make?
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T09%3A54%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Respiratory%20distress%20syndrome%20in%20preterm%20infants%20of%20less%20than%2032%20weeks:%20What%20difference%20does%20giving%20100%20or%20200mg/kg%20of%20exogenous%20surfactant%20make?&rft.jtitle=Pediatric%20pulmonology&rft.au=Lanciotti,%20Lucia&rft.date=2022-09-01&rft.volume=57&rft.issue=9&rft.spage=2067&rft.epage=2073&rft.pages=2067-2073&rft.issn=8755-6863&rft.eissn=1099-0496&rft_id=info:doi/10.1002/ppul.25979&rft_dat=%3Cproquest%3E2704843788%3C/proquest%3E%3Cgrp_id%3Ecdi_FETCH-proquest_journals_27048437883%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2704843788&rft_id=info:pmid/&rfr_iscdi=true