Hydroxyapatite nanoparticle-enriched thiolated polymer-based biocompatible scaffold can improve skin tissue regeneration

Hydroxyapatite has been extensively used in bone tissue regeneration but its application in skin tissue engineering and the underlying molecular mechanism remains unexplored. In the present study, we have developed a polymer hybrid scaffold functionalized with hydroxyapatite nanoparticles. Thiolated...

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Bibliographic Details
Published in:Journal of materials research 2021-11, Vol.36 (21), p.4287-4306
Main Authors: Kamnoore, Devanand, Mukherjee, Dhrubojyoti, Nayak Ammunje, Damodar, Parasuraman, Pavadai, Teja, Banala Venkatesh, Radhika, M.
Format: Article
Language:English
Subjects:
Applied and Technical Physics
Biocompatibility
Biomaterials
Biomedical materials
Chemistry and Materials Science
Chitosan
Glycogens
Growth factors
Hydroxyapatite
In vivo methods and tests
Inorganic Chemistry
Kinases
Materials Engineering
Materials research
Materials Science
Melting
Nanocomposites
Nanoparticles
Nanotechnology
Polyethylene glycol
Polymers
Regeneration (physiology)
Scaffolds
Tissue engineering
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Summary:Hydroxyapatite has been extensively used in bone tissue regeneration but its application in skin tissue engineering and the underlying molecular mechanism remains unexplored. In the present study, we have developed a polymer hybrid scaffold functionalized with hydroxyapatite nanoparticles. Thiolated chitosan was combined with thiolated eudragit and polyethylene glycol to form the scaffold using the freeze–thawing technique. During the freeze–thawing process, the scaffolds were functionalized with hydroxyapatite nanoparticles. FTIR and XRD studies confirmed the polymeric interlinking in the scaffold during the freeze–thawing method. SEM and micro-CT analysis indicated the functionalization of the nanoparticle on the scaffold moiety and a spongy structure of the nanocomposite scaffold with controlled pore intensity. In silico study in corroboration with in vivo evaluation indicated that the component of the nanocomposite scaffold acts via controlling the actions of epidermal growth factor and glycogen synthase kinase and may prove to be a suitable material for tissue engineering. Graphic abstract
ISSN:0884-2914
2044-5326
DOI:10.1557/s43578-021-00405-0