Immunopathology caused by impaired CD8+ T‐cell responses

Recent findings indicate that many immunopathologies are at their roots a consequence of impaired immune responses (“too little” immunity) and not the result of primarily exaggerated immune responses (“too much” immunity). We have summarized this conceptional view as “IMPATH paradox.” In this review...

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Bibliographic Details
Published in:European journal of immunology 2022-09, Vol.52 (9), p.1390-1395
Main Authors: Aichele, Peter, Neumann‐Haefelin, Christoph, Ehl, Stephan, Thimme, Robert, Cathomen, Toni, Boerries, Melanie, Hofmann, Maike
Format: Article
Language:English
Subjects:
Antigen presentation
Antigen-presenting cells
CD8 antigen
CD8+ T cells
chronic viral hepatitis
Hepatitis
Histiocytosis
immunopathology
Inflammation
Lymphocytes T
Lymphocytosis
primary hemophagocytic lymphohistiocytosis
Therapeutic applications
T‐cell exhaustion
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