Short-term Effect of LDL-Apheresis on Lipid Profile of Patients with Nephrotic and Non-Nephrotic Hyperlipidemia: A Comparative Study

• Published in: Electronic journal of general medicine 2021-06, Vol.18 (3), p.em295
• Main Authors: Gaipov, Abduzhappar, Nogaibayeva, Assem, Turebekov, Zaiyrkhan, Zharmukhanbet, Lyazzat, Orazbayev, Gani, Malykh, Dmitriy, Kim, Natalya, Abbay, Anara, Tuganbekova, Saltanat, Aljofan, Mohamad, Bekishev, Bolat
• Format: Article
• Language: English
• Subjects: Apheresis; High density lipoprotein; Hyperlipidemia; Kidney diseases; Lipids; Lipoproteins
• ISSN: 2516-3507; 2516-3507
• DOI: 10.29333/ejgm/10861

Background: Persistent hyperlipidemia is a major cause of cardiovascular morbidity in patients with nephrotic and non-nephrotic patients. Low-density lipoprotein-apheresis (LDL-apheresis) was shown to rapidly remove lipid structures. The current study aimed to compare the initial lipid profiles in patients with nephrotic syndrome and non-nephrotic hyperlipidemia as well as to evaluate the lipid profile of each group following a single treatment with LDL-apheresis. Methods: This is an open-label observational cross-sectional study of patients treated with LDL-apheresis including ten patients with nephrotic syndrome and thirteen patients with non-nephrotic hyperlipidemia who were either resistant and/or intolerant of lipid lowering therapy, with normal kidney function. Routine blood tests with full traditional lipid profile (Total cholesterol-(TC), Low-density lipoprotein (LDL), High-density lipoprotein (HDL), Triglycerides-(TG)) were determined before and after 12-hours following a single LDL-apheresis procedure. Results: Both groups were comparable by sex and age with more males than female in both groups. Baseline lipid profile was different between the two groups with nephrotic syndrome patients having significantly higher TC (p=0.05), LDL (p